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People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Finasteride may affect PNMT, causing side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.

Plant-based chemicals may help hair growth and prevent hair loss but need more research to compete with current treatments.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

Testosterone helps human pancreatic cells increase insulin release.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.