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This study reports that in human glioblastoma and neuroblastoma cell lines, 24-hydroxycholesterol significantly suppressed the conversion of testosterone to growth-inducing androgens via the 5α-reductase pathway, revealing a new connection between cholesterol homeostasis and androgen metabolism.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.

This review discusses the role of skeletal muscle in synthesizing bioactive androgens, highlighting that intramuscular androgens may influence muscle via intracrine action, but their precise function remains unclear.

In this study, researchers observed that RE-ORGA, a preparation from Korean herbs, may help alleviate androgenic alopecia by promoting human dermal papilla cell proliferation, reducing 5α-reductase enzyme levels, and displaying anti-inflammatory properties, suggesting potential regulation of androgen receptor sensitivity.

This study found that dutasteride affected spinal bone formation in curdlan-treated SKG mice, while DHT treatment reduced osteoblast differentiation in vitro, suggesting that DHT inhibition might unexpectedly increase spinal ankylosis progression in ankylosing spondylitis patients.

This study observed that CXCL12 is highly co-expressed with androgen receptors in human hair follicle cells, and its inhibition via antibodies increased hair length, suggesting a potential treatment strategy for androgenic alopecia.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Women treated with X-ray for scalp fungus as children had a higher chance of hair loss, especially with higher radiation doses and severe fungus infections.

This review explores the complex role of the Innate Immune System in rheumatoid arthritis, highlighting gaps in understanding its functions and interactions with the Adaptive Immune System, offering insights into potential biomarkers and therapeutic strategies for this challenging autoimmune condition.

This report describes two rare cases of desmoplastic melanoma presenting as alopecia neoplastica, highlighting a potential diagnostic pitfall for clinicians examining patients with scar-like alopecia.

This study observed that men who conform more strongly to traditional masculinity norms are likelier to undergo cosmetic surgery as a way to assert power, success, dominance, and sexual success.

This report describes six patients experiencing significant relief from migraine symptoms after undergoing hair transplantation.

The CSTAR registry, the largest in China for SLE, reports more than 25,000 patients registered since 2009, detailing demographics, clinical characteristics, and providing data for future studies.

In this study, low-dose oral minoxidil was found to have a favorable safety profile for treating alopecia, with mostly mild side effects, in both general and hypertensive populations.

This case report describes a postmenopausal woman with virilization linked to ovarian stromal hyperthecosis, highlighting the importance of detailed clinical evaluation and complementary testing for accurate diagnosis and treatment.

This review discusses the dermatological applications and potential health benefits of Epigallocatechin-gallate (EGCG) from green tea, but provides no new clinical findings.

This review discusses the potential of low-dose oral minoxidil as a safe and effective treatment for certain hair disorders, including alopecia, but reports no new clinical results.

This study found that mycophenolate mofetil was associated with higher response rates and lower rates of serious side effects, including a lower mortality rate, compared to cyclophosphamide in lupus nephritis treatment.

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.

In this study, original natural organic cosmetics with a natural index of ≥ 90% and efficacy patents increased purchase intention and reduced promotional dependency in the US market.

This study found that while men's facial appearance, specifically attractiveness and masculinity, correlated with cardiometabolic indicators like insulin resistance and triglycerides, these links disappeared after adjusting for factors such as age, adiposity, and testosterone levels, suggesting that facial cues do not reliably indicate metabolic health.

This study found that reducing BMP signaling in mouse nipple epithelia, achieved through Noggin overexpression, can convert them into hairy skin with pilosebaceous units.

This study found that a serum-free DMEM-F12 medium with 45% oxygen best supports in vitro development and differentiation of human fetal skin, closely mimicking the in vivo state.

This study found that direct immunofluorescence of hair is a simple and non-invasive alternative for monitoring pemphigus vulgaris, matching skin biopsy results in the cases observed.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

This review discusses recent developments in α1-adrenoceptor antagonists and 5α-reductase inhibitors for treating benign prostatic hyperplasia, reporting no new clinical results while identifying potential areas for future drug development.

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.