Role of Direct Immunofluorescence on Outer Root Sheath of Hair Follicle in Monitoring Disease Activity of Pemphigus Vulgaris

September 2017 in “ Journal of Pathology of Nepal ”

Mst. Sayedatun Nessa, Nurul Akmn Kabir, Ashim Ranjan Barua, Harasit Kumar Paul

direct immunofluorescence outer root sheath hair follicle pemphigus vulgaris skin biopsy scalp hair samples immune system skin mucous membranes DIF hair root sheath hair

TLDR Testing hair roots with a special dye is a simple, non-invasive way to check disease progress in pemphigus vulgaris patients.

The study investigated the effectiveness of using direct immunofluorescence on the outer root sheath of hair follicles to monitor disease activity in patients with pemphigus vulgaris, a condition where the immune system attacks the skin and mucous membranes. The study included 16 patients who had been in clinical remission for at least three months. Both skin biopsy samples and plucked scalp hair samples were stained and analyzed. The results showed that direct immunofluorescence was positive in 13 out of 16 patients (81.25%) for both hair and skin samples. The conclusion drawn from the study was that direct immunofluorescence of hair is a simple, specific, and non-invasive method that can potentially replace repeated skin biopsies for monitoring disease activity in pemphigus vulgaris patients.

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research Role of Direct Immunofluorescence on Outer Root Sheath of Hair Follicle in Monitoring Disease Activity of Pemphigus Vulgaris

1 citations, September 2017 in “Journal of Pathology of Nepal”

Testing hair roots with a special dye is a simple, non-invasive way to check disease progress in pemphigus vulgaris patients.