Effects of Dihydrotestosterone on Osteoblast Activity in Curdlan-Administered SKG Mice and Osteoprogenitor Cells in Patients with Ankylosing Spondylitis

    May 2020 in “ Arthritis research & therapy ”
    Sungsin Jo, Eun‐Ju Lee, Bora Nam … So Yeon Kim
    Studysummary This study found that dutasteride affected spinal bone formation in curdlan-treated SKG mice, while DHT treatment reduced osteoblast differentiation in vitro, suggesting that DHT inhibition might unexpectedly increase spinal ankylosis progression in ankylosing spondylitis patients.
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    Research cited in this study 1

    1. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012

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