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Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

Finasteride effectively treats male hair loss, improving growth and density.

Finasteride improves hair growth in men with androgenetic alopecia.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

Finasteride negatively affects fish reproduction and gonadal development.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.