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Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.

Finasteride harms Daphnia magna's reproduction, growth, and metabolism.

Solanum nigrum may help treat hair loss.

Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Gene differences may affect baldness treatment response in Korean men.

The study created a new method to test drugs that affect hormone processing in skin.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

A new compound effectively inhibits human 5α-reductase 1.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Licorice extract helps hair growth and may treat hair loss.