37 citations
,
January 2011 in “Annals of Dermatology” In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.
37 citations
,
September 2003 in “Journal of Medicinal Chemistry” This study found that compound 2g inhibits steroid sulfatase effectively without exhibiting estrogenic activity, making it a promising candidate for breast cancer treatment.
32 citations
,
March 2021 in “Journal of cosmetic dermatology (Print)” This letter to the editor discusses a potential link between new onset alopecia areata and SARS-CoV-2 infection, but reports no new clinical results.
32 citations
,
April 1999 in “Expert Opinion on Investigational Drugs” Clinical studies reported that finasteride reduces scalp dihydrotestosterone levels and improves hair growth in men with androgenetic alopecia, supporting its role as a treatment option.
29 citations
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April 2019 in “BMJ. British medical journal” This study concluded that men with benign prostatic hyperplasia receiving steroid 5α-reductase inhibitors, such as dutasteride or finasteride, have a higher risk of developing new onset type 2 diabetes compared to those taking tamsulosin.
28 citations
,
November 2014 in “Current Diabetes Reports” This review discusses the complex links between polycystic ovary syndrome, insulin resistance, and potential metabolic risks starting in adolescence, noting the need for early screening and treatment but reports no new clinical results.
23 citations
,
June 2012 in “Molecular Biology Reports” This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.
14 citations
,
September 2001 in “Archives of Dermatological Research” This study reported that Sonic hedgehog signaling is crucial for hair follicle development, with its expression being significantly induced in normal embryonic hair germs but inhibited in certain experimental models.
13 citations
,
August 2016 in “Medical Hypotheses” This review discusses the potential of evaluating hair follicle characteristics as early indicators of vascular impairment and organ damage in pre-diabetic individuals, but reports no new clinical results.
9 citations
,
November 2012 in “Biomolecules & therapeutics” This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.
9 citations
,
January 2008 in “Acta histochemica et cytochemica” This study found that COX-2 expression in normal rat skin is linked to the hair cycle, with varying levels observed in different skin structures during anagen, catagen, and telogen phases.
8 citations
,
March 2021 in “Drug testing and analysis” This study improved a hair analysis method to estimate the days of continuous ingestion of hay-fever medicines, with an average error of about 2 days from actual ingestion.
6 citations
,
November 2022 in “BMC Urology” In this study, researchers found that the microRNA miR-1199-5p may reduce the expression of SRD5A2 in benign prostatic hyperplasia tissues, potentially contributing to the failure of 5-α reductase inhibitor therapy in some patients.
4 citations
,
March 2014 in “The FASEB Journal” This study observed that deleting ARNT in keratinocytes of mice reduced zigzag hair production and altered hair follicle differentiation, likely by affecting the expression of specific cyclin-dependent kinase inhibitors.
3 citations
,
January 2021 in “Oxidative Medicine and Cellular Longevity” In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.
3 citations
,
December 1994 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” In this study, itraconazole was shown to accumulate in the deeper skin layers of guinea pigs after oral administration, suggesting this delivery method effectively targets infective organisms there.
2 citations
,
February 2022 in “Preprints.org” This study found that fermented red ginseng marc alleviated skin lesions, reduced inflammation, and demonstrated antioxidant effects in an AD-like mouse model, suggesting potential therapeutic applications for atopic dermatitis.
2 citations
,
November 2017 in “PloS one” This study found that 2MbisP increases epidermal thickening more rapidly than atRA in rhino mice, while both compounds similarly reduce utricle size.
2 citations
,
January 2012 in “Hair therapy & transplantation” This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.
1 citations
,
January 2015 in “Hair transplant forum international” This review discusses low level laser therapy for hair loss but reports no new research findings; it serves as an introduction to understanding existing knowledge before upcoming evaluations of recent studies.
1 citations
,
February 2020 in “Drug Design Development and Therapy” Low-dose Minoxidil combined with Spironolactone helps reduce hair loss and improve hair density in women, with some mild side effects.
October 2025 in “Journal of Neurophysiology” In this study, researchers identified two types of potassium channels, BK and Kv4.2, in rat Merkel cells and reported that these channels play important roles in repolarizing action potentials and maintaining resting membrane potentials, potentially influencing tactile encoding in these cells.
September 2025 in “Psychoneuroendocrinology” This study observed that while hair glucocorticoids were linked to type 2 diabetes, there was no social gradient in glucocorticoid levels among different socioeconomic groups, suggesting these biomarkers may not significantly contribute to understanding socioeconomic health disparities in diabetes.
February 2025 in “International Journal of Molecular Sciences” In this study, researchers identified significant differences in lipid composition between grey and black hair follicles in women with type 2 diabetes and healthy controls, suggesting these lipids may contribute to the production of grey hair and may offer targets for anti-grey-hair treatments.
January 2025 in “il Diabete” This study explores potential strategies for targeted drug delivery specifically to pancreatic beta-cells in type 2 diabetes treatment, highlighting methods for inducing drug expression in beta-cells, suitable drug carriers, active targeting peptides, and optimal administration routes.
May 2024 in “Frontiers in Immunology” In this mini-review, recent insights suggest a possible role of type-2-related immunity in diseases like alopecia areata, vitiligo, and localized scleroderma, though whether this immune response benefits or worsens these conditions remains unclear.
January 2024 in “Srpski arhiv za celokupno lekarstvo” In this study, patients with diabetic retinopathy and peripheral occlusive arterial disease had significantly longer diabetes duration, higher HbA1c levels, poorer glycemic control, and were more often smokers compared to those without arterial disease, suggesting these factors contribute to disease development.
April 2018 in “Journal of Investigative Dermatology” The researchers reported that nicotinic acid normalized excessive sebaceous lipogenesis without affecting basal lipogenesis and suggested potential anti-acne benefits.
January 2015 in “OpenBU/Boston University Institutional Repository (Boston University)” This study reported that NRP2 expression in melanocytes and melanocyte stem cells is linked to migration inhibition and potentially melanoma progression, suggesting its role as a target for understanding melanoma and hair follicle biology.
April 2010 in “Cancer Research” This study found significant upregulation of IDO-1 and IDO-2 in human basal cell carcinomas, suggesting that IDO production may confer immune privilege characteristics to the tumors, potentially impacting their growth.