Lipidomics and Network Pharmacology to Explore Mechanisms of Grey Hair Development in Type 2 Diabetes and Normal Populations (Female)

This study examined the differences in lipid composition between grey and black hair follicles in women with type 2 diabetes and healthy individuals, involving 41 diabetic and 35 healthy female volunteers aged 55–65. It found significant differences in lipid profiles, with specific lipids like emmotin A and fucoxanthinol 3-heptadecanoate 3′-myristate being higher in grey hair. The research suggests that these lipid differences could serve as diagnostic markers or therapeutic targets for grey hair. Key genes and pathways related to hair growth and melanin synthesis, such as PIK3R1, AKT1, and MAPK1, were identified, and potential anti-grey-hair ingredients like resveratrol and calycosin were highlighted. The findings indicate that altered lipid pathways in diabetic patients may contribute to premature greying, providing insights into the biological processes underlying hair pigmentation changes.