Lipidomics and Network Pharmacology to Explore Mechanisms of Grey Hair Development in Type 2 Diabetes and Normal Populations (Female)

    February 2025 in “ International Journal of Molecular Sciences ”
    Liwen Wu, Shiqi Li, Congfen He
    Studysummary In this study, researchers identified significant differences in lipid composition between grey and black hair follicles in women with type 2 diabetes and healthy controls, suggesting these lipids may contribute to the production of grey hair and may offer targets for anti-grey-hair treatments.
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    Research cited in this study 8

    1. Adipose Transcriptome in the Scalp of Androgenetic Alopecia Frontiers in Medicine · 2023
    2. Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways British Journal of Dermatology · 2022
    3. Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads Journal of Bioscience and Bioengineering · 2022
    4. Exploration of Potential Lipid Biomarkers for Premature Canities by UPLC-QTOF-MS Analyses of Hair Follicle Roots Experimental dermatology · 2020
    5. Three Streams for the Mechanism of Hair Graying Annals of dermatology/Annals of Dermatology · 2018
    6. The Hair Follicle Enigma Experimental Dermatology · 2017
    7. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    8. Effects of Hura Crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation Biological & Pharmaceutical Bulletin · 2012