Upregulation of miR-1199-5p Is Associated With Reduced Type 2 5-Alpha Reductase Expression in Benign Prostatic Hyperplasia

November 2022 in “ BMC Urology ”

Zhanliang Liu, Zhemin Lin, Fang Cao, Mingxin Jiang, Song jin, Yun Cui, YN Niu

miR-1199-5p type 2 5-α reductase SRD5A2 benign prostatic hyperplasia 5-α reductase inhibitor 5-ARI finasteride Propecia

Studysummary In this study, researchers found that the microRNA miR-1199-5p may reduce the expression of SRD5A2 in benign prostatic hyperplasia tissues, potentially contributing to the failure of 5-α reductase inhibitor therapy in some patients.

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The study explored the role of miR-1199-5p in regulating the expression of type 2 5-α reductase (SRD5A2) in benign prostatic hyperplasia (BPH) and its potential impact on the effectiveness of 5-α reductase inhibitor (5-ARI) therapy. It was found that miR-1199-5p was significantly upregulated in BPH tissues with negative or weak SRD5A2 expression, suggesting that miR-1199-5p might contribute to the variability in SRD5A2 expression. This upregulation was associated with decreased sensitivity to finasteride, a 5-ARI, indicating that miR-1199-5p could be a factor in the resistance to 5-ARI therapy. The study involved 59 BPH specimens and highlighted the need for further research due to limitations such as a small sample size and the inclusion of patients previously treated with 5-ARIs.

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Research cited in this study

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