Upregulation of miR-1199-5p Is Associated With Reduced Type 2 5-Alpha Reductase Expression in Benign Prostatic Hyperplasia

    November 2022 in “ BMC Urology ”
    Zhanliang Liu, Zhemin Lin, Fang Cao … YN Niu
    Studysummary In this study, researchers found that the microRNA miR-1199-5p may reduce the expression of SRD5A2 in benign prostatic hyperplasia tissues, potentially contributing to the failure of 5-α reductase inhibitor therapy in some patients.
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    Research cited in this study 4

    1. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    2. Structure of Human Steroid 5α-Reductase 2 with Anti-Androgen Drug Finasteride Research Square (Research Square) · 2020
    3. Reduced Levels of 5-Alpha Reductase 2 in Adult Prostate Tissue and Implications for BPH Therapy ˜The œProstate/˜The œprostate · 2011
    4. Estrogen and Androgen Signaling in the Pathogenesis of Benign Prostatic Hyperplasia Nature reviews. Urology · 2011