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This phase I study reported that ETC-159, targeting Wnt signalling, showed tolerable safety profiles at doses that inhibit its pathway, though bone turnover markers increased, warranting early and regular monitoring. No tumor responses were observed, but two patients achieved stable disease for several cycles.

This study found that exercise decreases the expression of 5αR1, thereby enhancing the PI3K/AKT signaling pathway in PCOS rats.

In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.

The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.

This article reviews multiple entries on the Androlog blog regarding finasteride use, concluding that a 1-mg dose does not adversely affect spermatogenesis or pose a risk during conception or pregnancy.

This study found that 32% of men continued finasteride use for 1 to 3 years, with many reporting poor hair growth results.

This study reports that using molecular docking methods, beta-sitosterol and stigmasterol from Serenoa repens were identified as potential natural inhibitors of the 5AR1 enzyme, which could serve as novel treatments for androgenetic alopecia based on their inhibitory action observed in a laboratory setting.

This study found that 1 mg/day low-dose oral minoxidil significantly increased hair count compared to 0.25 mg/day over 24 weeks in women with female pattern hair loss, though no differences were observed in hair-shedding and quality-of-life scores between the two doses.

In this case report, a girl with autoimmune polyglandular syndrome type 1 experienced stabilized disease and reversal of alopecia universalis after treatment with glucocorticoids and methotrexate.

This study reported that atelocollagen enhances collagen synthesis and reduces oxidative stress in aged skin by increasing glycine uptake through GlyT1, resulting in improved skin elasticity and collagen density in aged mice, with effects superior to glycine alone.

In this study, researchers found that recombinant human HAPLN1 promoted hair growth in mice and human hair matrix cells by activating specific signaling pathways, suggesting it may offer a potential hair loss treatment with fewer side effects than existing medications.

This study determined that men taking finasteride 1 mg/day exhibited significantly reduced sperm production and morphology compared to controls, although there were no notable changes in hormonal, sexual, or psychological function.

This study found that men taking 1 mg/day of finasteride had significantly reduced sperm production and morphology but similar hormonal, sexual, and psychological profiles compared to controls, suggesting finasteride affects semen quality without altering other physiological functions.

This research describes CG2001's promising safety profile and reduced systemic exposure as an alternative to finasteride, supporting its further development for androgenic alopecia treatment in future trials.

In this study, oral minoxidil treatment at 2.5 mg/day significantly increased nail growth speed by 50.7% and hair growth speed by 35.9% in healthy adult men, while also increasing heart rate but not affecting blood pressure.

This case report highlights a rare presentation of APS-1 in a 28-year-old Pakistani male with cardiovascular and pulmonary symptoms, illustrating the importance of early recognition and multidisciplinary management for improved patient outcomes.

This study found that finasteride induced infertility and increased endoplasmic reticulum stress in rats, but these effects were mitigated by DA-9401 administration.

Oral minoxidil effectively reduces hair shedding in women with chronic telogen effluvium.

Oral minoxidil significantly reduces hair shedding in women with chronic telogen effluvium.

This study found that minoxidil sulfate enhanced hair growth in CRF-OE mice, with increased hair growth scores observed at 2 and 4 weeks after treatment.

The new topical product combined with finasteride significantly increased hair thickness without side effects.

In this study, 32% of men continued taking finasteride for androgenetic alopecia after 1 to 3 years, but only a small percentage reported hair growth.

In this study, finasteride was found to significantly reduce DHT levels and affect spermatogenic markers in rats, while DA-9401 co-treatment indicated potential ameliorative effects.

This study found that the risk of persistent sexual dysfunction was higher in men who stopped using finasteride 1 mg compared to omeprazole users.

This study found that five 0.1 mg dutasteride capsules are bioequivalent to one 0.5 mg dutasteride capsule in healthy adult males under fasting conditions, and both were well tolerated.

This review discusses the sexual side effects of long-term finasteride usage in men, noting varied reports of sexual dysfunction which typically improve over time; it presents no new experimental data.

This article discusses a critique of a lecture on post-Finasteride syndrome from the ISHRS 2015 World Congress and does not report new research findings.

This study found that finasteride 1 mg was effective in improving androgenetic alopecia over 10 years in men, particularly those older than 30, with some reporting beneficial results even after 5 years.