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Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Testosterone may slow down wound healing and increase inflammation.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Men with male pattern baldness don't necessarily have high levels of Dehydroepyandrosterone-sulfate, and there's no link between its levels and the severity of hair loss.

Men with hair loss don't necessarily have higher levels of the hormone DHEA-S, but this hormone tends to decrease with age.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The conclusion is that new plant-based treatments for hair loss may work by targeting certain enzymes.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.