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Glossary Androgen Action

biological effects triggered by male sex hormones like testosterone

Androgen action refers to the biological effects triggered by androgens, which are male sex hormones like testosterone. These hormones bind to specific receptors in cells, influencing the development and maintenance of male characteristics, such as facial hair and muscle mass, and also play roles in female health. In the context of hair, androgen action can lead to hair growth in certain areas and contribute to conditions like androgenetic alopecia (pattern baldness).

Related Terms

Research

5 / 1000+ results

research Androgen action on human skin – from basic research to clinical significance

147 citations , October 2004 in “Experimental dermatology”

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

research Androgen actions on the human hair follicle: perspectives

115 citations , September 2012 in “Experimental Dermatology”

This article reviews the molecular mechanisms involved in androgenetic alopecia and the androgen's paradoxical role in hair growth, but reports no new experimental findings.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

This review discusses the physiological roles of ovarian androgens in follicle development and atresia, emphasizing their contributions to polycystic ovary syndrome and normal follicle maturation but provides no new clinical results.

Antiandrogen Drugs Lower Serum Prostate-Specific Antigen Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women

research Antiandrogen Drugs Lower Serum Prostate-Specific Antigen (PSA) Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women¹

16 citations , January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.

research Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin?

14 citations , November 1982 in “British Journal of Dermatology”

This article discusses whether testosterone's metabolism to 5α-dihydrotestosterone is necessary for androgenic effects in the skin but reports no new experimental results.

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Community Join

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community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

14 upvotes 6 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Best advice when it comes to MPB is don't be in denial

22 upvotes 6 years ago

The conversation is about the importance of acting quickly against hair loss. The user shares their experience with androgenic alopecia and mentions using finasteride without improvement.

community Pyrilutamide for Hair Loss!? (Ft. Steve Cook)

in Satire 4 upvotes 4 months ago

Pyrilutamide is discussed as a potential hair loss treatment, acting as an androgen receptor antagonist. The conversation questions if it can maintain hair long-term without using finasteride.

community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 3 years ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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Learn

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learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Spironolactone

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn Argan oil

Argan oil: Is it useful for androgenic alopecia, or just for making hair look nice? Argan oil primarily improves hair appearance but lacks proven effectiveness for androgenic alopecia.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Microneedling

Does microneedling help with all types of alopecia, or only androgenic alopecia? Microneedling is most effective for androgenic alopecia, with limited evidence for other types.

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