A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds

    December 2024 in “ Pharmaceutics ”
    Saedah Dereiah, Muhammad Usman Ghori, Barbara R. Conway
    Image of study
    TLDR Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.
    This systematic review evaluates spironolactone (SP) nano-formulations for topical treatment of skin hyperandrogenic disorders and chronic wounds, analyzing 13 articles and 15 studies. It highlights the potential of various nanocarriers, such as lipid nanoparticles, vesicular nanoparticles, polymeric nanoparticles, and nanofibers, to improve SP's bioavailability and skin penetration for conditions like acne, alopecia, hirsutism, and rosacea. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) offer improved drug stability and release, with NLCs showing faster drug release. Ethosomes demonstrated superior skin penetration, while polymeric nanoparticles effectively target hair follicles. Despite promising results, further clinical studies are needed to optimize safety, efficacy, and therapeutic doses of these nano-formulations.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 455 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 4 months ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 4 months ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 6 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 1 year ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

    Similar Research

    5 / 1000+ results