HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation

    December 2019 in “ International Journal of Molecular Sciences ”
    Nahyun Choi, Won Serk Kim, Sang Ho Oh, Jong-Hyuk Sung
    Studysummary This study found that preconditioning adipose-derived stem cells with HB-EGF enhanced their ability to promote hair growth in vivo by increasing their motility, paracrine effects, and survival.
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    Research cited in this study 13

    1. Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells Biomolecules & Therapeutics · 2019
    2. Generation of Trichogenic Adipose-Derived Stem Cells by Expression of Three Factors Journal of Dermatological Science · 2018
    3. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    4. LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway Stem cell research & therapy · 2016
    5. Hair Regeneration Using Adipose-Derived Stem Cells PubMed · 2016
    6. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016
    7. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    8. Functional Regulation of Adipose-Derived Stem Cells by PDGF-D Stem Cells · 2014
    9. Isolation of Adipose-Derived Stem Cells Using a Subfractionation Culturing Method Expert Opinion on Biological Therapy · 2014
    10. Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species Stem Cells and Development · 2012
    11. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells Stem Cells and Development · 2011
    12. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    13. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003