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    Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Cells

    September 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Yihong Chen, Chrysostomi Gialeli, Jiaxu Shen … Jan Nilsson

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, FOL-026, a peptide based on osteopontin, was shown to promote angiogenesis and stimulate vascular cell proliferation and migration through neuropilin-1, similar to VEGF, suggesting potential therapeutic applications in vascular repair and angiogenesis-related conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Signaling by Senescent Melanocytes Hyperactivates Hair Growth Nature · 2023
    2. A Novel Microparticle-Based Formulation for Topical Delivery of FOL-005, a Small Peptide Journal of Pharmaceutical Sciences · 2022
    3. The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis Frontiers in cell and developmental biology · 2021
    4. An Osteopontin-Derived Peptide Inhibits Human Hair Growth by Decreasing Fibroblast Growth Factor-7 Production in Outer Root Sheath Keratinocytes British Journal of Dermatology · 2019
    5. VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis Journal of Cellular and Molecular Medicine · 2017
    6. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    7. A Role of Placental Growth Factor in Hair Growth Journal of dermatological science · 2014
    8. Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model BMC dermatology · 2013
    9. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    10. Promoted Growth of Murine Hair Follicles Through Controlled Release of Vascular Endothelial Growth Factor Biomaterials · 2002
    11. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    12. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    13. The Secret Life of the Hair Follicle Trends in genetics · 1992