Gradient pH Hydrogel Promotes Infected Wound Healing Through pH Regulation of Microenvironment

June 2025 in “ Biomacromolecules ”

Yan Yang, Shizhuo Li, Yixuan Li, Mengyue Zhang, Shitong Li, Kun Liu, Tong Qiu, Honglian Dai

GelMA-based hydrogel pH regulation fibroblasts endothelial cells macrophage polarization M2 macrophages neovascularization hair follicle regeneration Treg cells

Studysummary In this study, researchers developed a GelMA-based gradient pH hydrogel that effectively reduced bacterial load and promoted fibroblast and endothelial cell proliferation, macrophage polarization, neovascularization, and hair follicle regeneration, offering a promising treatment for bacterially infected skin wounds.

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