Dermal Fibroblasts in Cutaneous Development and Healing

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.

This article discusses the roles of dermal papilla and sheath cells in hair follicle formation and regeneration but reports no new clinical findings, emphasizing the need for further research on these fibroblasts.

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.

This review revisits the mechanisms of wound induced hair follicle neogenesis in mice and concludes that the process involves canonical WNT signaling activated by Fgf9 from γδ T cells, but more research is needed to fully understand its cellular bases.

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

This review explores the evolution and development of skin-associated adipose tissue and proposes new nomenclature for the cells and adipose tissue underlying the reticular dermis, without reporting clinical results.

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.

This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.

This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

In this study, researchers showed that Wnt ligands secreted by hair follicle epithelium are crucial for hair follicle regeneration and may be significant for treating hair disorders like alopecia.

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

Nephronectin helps attach muscle cells to hair follicles.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.

In this study, fetal rat wounds at gestational age 16 days healed without scar formation and resembled normal skin architecture, unlike those at 18 days which resulted in scarring and lack of hair follicles.

This study found that Msx2-deficient mice exhibit skull and bone formation defects similar to those seen in human MSX2-related conditions, highlighting the gene's importance in skeletal and organ development.

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.