Topical Immunotherapies

January 2024 in “ Elsevier eBooks ”

Cynthia Truong, Katharina S. Shaw, Kristen Lo Sicco, Jerry Shapiro

androgenetic alopecia follicular microinflammation topical prostaglandin analogs topical irritants topical sensitizers topical steroids intralesional steroids alopecia areata cicatricial alopecia frontal fibrosing alopecia AGA topical prostaglandins scarring alopecia

TLDR Some treatments that modify the immune system might help with certain types of hair loss but haven't been explored for common hair loss alone.

Androgenetic alopecia (AGA), the most common cause of hair loss, is believed to be influenced by follicular microinflammation. Despite this, no immune modulatory therapies have been explored for AGA alone. Topical prostaglandin analogs could potentially be used for AGA treatment. Other immune modulatory therapies, such as topical irritants and sensitizers, as well as topical and intralesional steroids, are only recommended for AGA patients who also have alopecia areata or cicatricial alopecia. The document discusses the use of these topical and intralesional immunomodulatory agents for the treatment of alopecia areata or frontal fibrosing alopecia that may occur alongside AGA.

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33 / 33 results

research Frontal Fibrosing Alopecia: A Review

23 citations , April 2021 in “Journal of Clinical Medicine”

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

research Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis

19 citations , April 2020 in “Journal of the American Academy of Dermatology”

5 mg/mL of triamcinolone acetonide is most effective for hair regrowth with fewer side effects.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations , February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research Shedding Light on the FDA’s 510(k) Approvals Process: Low-Level Laser Therapy Devices Used in the Treatment of Androgenetic Alopecia

6 citations , July 2019 in “Journal of Dermatological Treatment”

LLLT devices for hair loss need more research to define proper guidelines.

research Frontal Fibrosing Alopecia: Efficacy of Treatment Modalities

14 citations , April 2019 in “International Journal of Women's Health”

Some treatments can stabilize Frontal Fibrosing Alopecia, but more research is needed to find effective treatments, and hair transplants often fail.

research Case Report of Novel Combination of Anthralin and Calcipotriene Leading to Trichologic Response in Alopecia Areata

6 citations , March 2019 in “JAAD case reports”

A new mix of anthralin and calcipotriene might help treat severe hair loss.

research Distinguishing Immunohistochemical Features of Alopecia Areata from Androgenic Alopecia

3 citations , February 2019 in “Journal of Cosmetic Dermatology”

Biopsy can differentiate between alopecia areata and androgenic alopecia, and if more information is needed, testing for CD3 and CD8 can help.

research A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia

21 citations , February 2018 in “Journal of Dermatological Treatment”

Topical cetirizine improves hair density and thickness in androgenetic alopecia, but more research is needed.

research Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia

38 citations , March 2017 in “Expert Opinion on Investigational Drugs”

Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

47 citations , January 2017 in “Lasers in Surgery and Medicine”

Low-level laser therapy may improve hair regrowth and thickness for androgenetic alopecia, but more research is needed.

research Distinguishing Diffuse Alopecia Areata from Pattern Hair Loss Using CD3+ T Cells

19 citations , May 2016 in “Journal of The American Academy of Dermatology”

CD3+ T-cell presence is a reliable marker to tell apart alopecia areata from pattern hair loss.

research Treatment of Alopecia Areata With Topical Sensitizers

15 citations , January 2015 in “Dermatitis”

Topical immunotherapy is the best treatment for severe alopecia areata.

research How Effective Is Intralesional Injection of Triamcinolone Acetonide Compared with Topical Treatments in Inducing and Maintaining Hair Growth in Patients with Alopecia Areata? A Critically Appraised Topic

25 citations , April 2014 in “British journal of dermatology/British journal of dermatology, Supplement”

Intralesional triamcinolone acetonide can regrow hair in alopecia areata but often has temporary effects and side effects.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , April 2014 in “Journal of The American Academy of Dermatology”

Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.

research Current Treatment of Alopecia Areata

71 citations , December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

There are no FDA-approved treatments for Alopecia Areata, and current options have varying success and relapse rates.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations , March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

research Clinical and Histological Challenge in the Differential Diagnosis of Diffuse Alopecia: Female Androgenetic Alopecia, Telogen Effluvium and Alopecia Areata – Part I

29 citations , November 2012 in “Anais Brasileiros De Dermatologia”

Diagnosing hair loss disorders needs clinical, dermoscopic, and histological differences, and checking menstrual cycle, weight changes, drug therapy, and nail changes.

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations , May 2012 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

research Eyebrow Regrowth in Patients with Frontal Fibrosing Alopecia Treated with Intralesional Triamcinolone Acetonide

51 citations , October 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

Intralesional triamcinolone acetonide helps regrow eyebrows in patients with frontal fibrosing alopecia.

research Topical Immunotherapy in Alopecia Areata

45 citations , January 2010 in “International journal of trichology”

Topical immunotherapy, especially with DPCP, is effective for treating severe alopecia areata.

research Frontal Fibrosing Alopecia: A Survey in 16 Patients

123 citations , August 2005 in “Journal of the European Academy of Dermatology and Venereology”

The study found that Frontal Fibrosing Alopecia affects a broader age range of women and early treatment can help stop hair loss.

research Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

27 citations , January 2005 in “American Journal of Clinical Dermatology”

Azelaic acid and anthralin are similarly effective for treating patchy hair loss.

research Topical Prostaglandin F2α Analog Induced Poliosis

51 citations , May 2004 in “American journal of ophthalmology”

Using topical prostaglandin F2α for glaucoma may cause loss of eyelash or eyebrow pigment.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

research Efficacy of Betamethasone Valerate Foam Formulation in Comparison with Betamethasone Dipropionate Lotion in the Treatment of Mild-to-Moderate Alopecia Areata: A Multicenter, Prospective, Randomized, Controlled, Investigator-Blinded Trial

66 citations , July 2003 in “International Journal of Dermatology”

Betamethasone valerate foam is more effective and safe for treating mild-to-moderate alopecia areata than betamethasone dipropionate lotion.

research Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis

146 citations , July 2003 in “Journal of the American Academy of Dermatology”

Clobetasol propionate ointment can help some people with total hair loss regrow hair.

research Fibrosing Alopecia in a Pattern Distribution

158 citations , February 2000 in “Archives of dermatology”

Some people with pattern hair loss may also have scalp inflammation and scarring similar to lichen planopilaris.

research Hair Regrowth

118 citations , April 1998 in “Dermatologic Clinics”

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

research Topical Tretinoin as an Adjunctive Therapy with Intralesional Triamcinolone Acetonide for Alopecia Areata: Clinical Experience in Northern Saudi Arabia

11 citations , April 1997 in “International Journal of Dermatology”

Using tretinoin with triamcinolone acetonide helps treat alopecia areata.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Cutaneous Immunopathology of Androgenetic Alopecia

13 citations , August 1991 in “The Journal of the American Osteopathic Association”

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

Anthralin cream helped 25% of patients with severe alopecia areata regrow hair, but caused skin irritation.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.

2 / 2 results

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , March 2019 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Treating Resistant Cases of Alopecia Universalis

May 2018 in “Journal of cosmetology & trichology”

Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.