Topical Prostaglandin F2α Analog Induced Poliosis

    Celia S. Chen, Jane R. Wells, Jamie E. Craig
    TLDR Using topical prostaglandin F2α for glaucoma may cause loss of eyelash or eyebrow pigment.
    In a case series from 2004, seven patients who were treated with topical prostaglandin F2α (PGF2α) analogs for primary open-angle glaucoma developed bilateral poliosis, which is the loss of pigment in eyelashes and/or eyebrows. This side effect occurred either alone or in combination with other adverse effects associated with PGF2α analog therapy. The study concluded that poliosis should be considered a possible adverse effect of topical PGF2α analog therapy, a connection that had not been reported prior to this study. Consequently, the use of topical PGF2α analogs should be considered when diagnosing patients with poliosis.
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