Latanoprost-Induced Skin Depigmentation

    November 2017 in “ Journal of Glaucoma
    Mark Po-Hung Lin, Mason Schmutz, Sameh Mosaed
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    Studysummary This case report documents a patient experiencing paradoxical depigmentation of the periocular skin after one year of using latanoprost, a finding not previously associated with this medication.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This article reports on a case of skin depigmentation in a patient using latanoprost eye drops for glaucoma treatment. The patient's skin depigmentation did not reverse after discontinuing other medications, but did show some improvement after discontinuing latanoprost. The article suggests that clinicians should be aware of this potential adverse effect and monitor for signs accordingly. The underlying mechanism behind these observations remains unknown, but it was hypothesized that individual follicular responses to prostaglandins may differ during the anagen phase of the cell cycle.
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