August 2024 in “Archives of Dermatological Research” This study found that in male patients with androgenetic alopecia, combining botulinum toxin type A with 5% Minoxidil significantly improved hair growth, patient satisfaction, and quality of life over six months, compared to using Minoxidil alone, without causing adverse effects.
January 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, researchers found that nanoparticles loaded with umbilical cord-derived stem cell membranes and minoxidil enhanced hair growth by improving drug solubility and transdermal delivery, increasing VEGF, IGF-1, MKI67, and CTNNB protein levels in skin tissue compared to regular minoxidil.
December 2023 in “Farmateka” Minoxidil is an effective and safe treatment for common hair loss when applied to the skin, but more research is needed for optimal use.
November 2023 in “International Journal of Medical Sciences” This review examines the mechanisms of hair follicle development and regeneration, discussing current hair loss treatments and emerging therapies like low-level laser therapy and stem cell therapy, which the authors suggest show promise in managing hair loss.
1 citations
,
July 2023 in “Cureus” This article examines advancements in understanding and managing androgenic alopecia (male pattern baldness), discussing genetic and psychological factors, diagnostic methods, classifications, and various treatment options, including traditional and emerging therapies, to aid healthcare professionals in making informed treatment decisions.
2 citations
,
July 2023 in “Vrach” In this review, researchers reported that plasma therapy, specifically PRP therapy, shows a high regenerative potential with low toxicity and beneficial effects like immunomodulation and soft tissue remodeling, suggesting its recommendation for broader clinical use based on most studies.
May 2023 in “Aesthetic Plastic Surgery” The document concludes that there are various surgical techniques for hair restoration, their success depends on the surgeon's skill, patient's health, and quality of donor hair, and they can potentially improve the mental well-being of those with hair loss.
This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.
This review suggests that stem cells might be a promising addition or alternative to standard treatments for androgenic alopecia, but larger studies are needed to confirm these findings.
2 citations
,
March 2023 in “Aesthetic Plastic Surgery” This article discusses a combined strip and follicular unit extraction method along with an intraoperative calculation model to reduce over-extraction and wastage in hair transplantation and reports no new clinical results.
March 2023 in “Медицинский совет” In this study, 77% of androgenetic alopecia patients showed hair regrowth with minoxidil treatment, while lower SULT1A1 enzyme activity, ATP concentration, and initial hair density were identified as negative prognostic factors for treatment response.
December 2022 in “Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei” In this study, researchers found that genetic and non-genetic factors, including deficiencies in micronutrients like zinc and vitamins, play varying roles in the development of androgenetic alopecia in men.
January 2022 in “Klinicheskaya dermatologiya i venerologiya” This study found that anisotrichia, yellow dots, and increased vellus hairs are key trichoscopic markers of early androgenetic alopecia, while late stages are characterized by anisotrichia, yellow dots, and increased single follicular units.
11 citations
,
October 2021 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical finasteride significantly increased hair count in men with androgenetic alopecia compared to placebo while maintaining similar efficacy to oral finasteride but with lower systemic exposure and a reduced impact on serum DHT levels, potentially minimizing sexual side effects.
8 citations
,
October 2021 in “Indian Journal of Plastic Surgery/Indian journal of plastic surgery” This study reviewed data from 2,896 hair transplant patients over 10 years, identifying sterile folliculitis, vasovagal shock, facial edema, and other minor complications, with no life-threatening issues reported. Detailed counseling and thorough medical history assessments are recommended to minimize risks.
11 citations
,
August 2021 in “Stem Cell Research & Therapy” This study reports that a single transplantation of autologous stromal vascular fraction significantly increased hair density and keratin score in androgenic alopecia patients within six months.
3 citations
,
May 2021 in “Indian Dermatology Online Journal” This article reviews the diverse uses of follicular unit extraction in treating various hair and skin conditions but reports no new clinical findings.
30 citations
,
April 2021 in “Journal of The American Academy of Dermatology” This review explains the evolution and current techniques of follicular unit transplantation for hair restoration, identifying conditions suitable for surgery and offering guidelines for dermatologists to assess candidate suitability, focusing on male and female pattern hair loss.
11 citations
,
March 2021 in “Cleveland Clinic Journal of Medicine” In this overview, the authors note that both pharmacologic and nonpharmacologic treatments are effective for pattern hair loss, emphasizing early detection and intervention to maintain hair.
102 citations
,
July 2020 in “International journal of molecular sciences” This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.
July 2020 in “Vestnik urologii” This review examines the contentious issue of post-finasteride syndrome linked to 5-alpha reductase inhibitors and reports mixed findings on its sexual, physical, and psychological effects; the authors call for more rigorous studies.
119 citations
,
May 2020 in “Journal of The American Academy of Dermatology” This study observed a high prevalence of androgenetic alopecia in patients hospitalized with severe COVID-19, with 79% of men and 42% of women affected, suggesting a potential link between androgen sensitivity and COVID-19 severity.
12 citations
,
April 2020 in “Facial Plastic Surgery Clinics of North America” This article discusses potential complications in hair restoration surgery and emphasizes the importance of thorough planning and patient participation in reducing risks, but reports no new clinical findings.
12 citations
,
April 2020 in “Facial Plastic Surgery Clinics of North America” This study reviews advancements in hair restoration surgery, noting that follicular unit excision significantly improves outcomes by enabling graft harvesting without scarring and reporting a graft transection rate under 4% when conducted with advanced equipment.
65 citations
,
April 2020 in “International Journal of Molecular Sciences” This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.
9 citations
,
March 2020 in “Dermatologic Surgery” This study found that both FUE and FUT methods are equally effective in producing high-quality hair grafts, with FUE offering the advantage of less noticeable scarring compared to FUT.
12 citations
,
October 2019 in “Aesthetic Plastic Surgery” 
28 citations
,
October 2017 in “Journal of Cosmetic and Laser Therapy” This study found that combining microneedle treatments with 5% minoxidil topical solution led to the greatest increase in hair density among Chinese men with androgenetic alopecia.
41 citations
,
September 2014 in “JAMA Facial Plastic Surgery” This review discusses current medical and surgical treatments for androgenetic alopecia, highlighting the use of finasteride and minoxidil for men and the role of hair transplantation techniques, without providing new clinical results.
