Prognostic Factors in the Treatment of Androgenetic Alopecia with Minoxidil

March 2023 in “ Медицинский совет ”

T.V. Tsimbalenko, Aida G. Gadzhigoroeva, N. N. Potekaev, G. P. Tereshchenko, E. V. Mikhalchik

minoxidil androgenetic alopecia SULT1A1 enzyme ATP concentration hair density hair regrowth Rogaine AGA

TLDR Minoxidil works better for hair regrowth if you have higher SULT1A1 enzyme activity and ATP concentration.

The study evaluated prognostic factors for the response to minoxidil treatment in 30 patients with androgenetic alopecia (AGA). After 4 months of using 5% topical minoxidil, 77% of participants showed hair regrowth and improvements in hair density and diameter. Key findings indicated that lower SULT1A1 enzyme activity, lower ATP concentration in plucked hairs, and lower baseline total hair density were negative prognostic factors for treatment response. A strong positive correlation was found between SULT1A1 enzyme activity and increased hair density, while a moderate positive correlation was observed between ATP concentration and hair density increase.

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