Androgenic Alopecia in Men: The Significance of Genetic, Hormonal, and Metabolic Factors

December 2022 in “ Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei ”

Irina N Kondrakhina

androgenic alopecia genetic predisposition hormonal imbalances androgens metabolic issues obesity diabetes microelements vitamins micronutrient insufficiency copper AA hormones metabolism nutrients

Studysummary In this study, researchers found that genetic and non-genetic factors, including deficiencies in micronutrients like zinc and vitamins, play varying roles in the development of androgenetic alopecia in men.

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The document presents a series of studies on androgenic alopecia (AA) in men, focusing on genetic, hormonal, and metabolic factors. The first study involved 500 men and found that 70% of participants with alopecia had a family history of the condition, 60% showed signs of hormonal imbalances, and 40% had metabolic issues like obesity and diabetes. The second study, involving 175 men, found that AA is associated with genetic predisposition and the action of androgens, but can also occur with normal hormonal levels due to non-genetic factors like harmful habits or environmental pollution. The third study, involving 50 patients, found that AA occurred against a background of multiple deficiencies of microelements and vitamins, but these deficiencies showed only weak correlations with significant changes in hair characteristics. The final study, involving 48 patients, identified a significant role of micronutrient relative insufficiency, particularly copper, in the development of AA. It also found that personalized correction of identified micronutrient status deviations allowed for highly effective therapy.

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research 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss

21 citations , November 2017 in “Archives of Dermatological Research”

This study found that women with female pattern hair loss had increased 5α-reductase isozymes and decreased aromatase mRNA levels, potentially affecting their response to treatment.

research GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

57 citations , November 2017 in “Nature Communications”

This genome-wide association study identified 71 genetic loci linked to male pattern baldness, with 30 novel loci, explaining 38% of the risk and suggesting shared pathways with lifespan and cancer traits.

research Alopecia and the Metabolic Syndrome

30 citations , September 2017 in “Clinics in Dermatology”

This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

research Changes of Serum Trace Elements Level in Patients with Alopecia Areata: A Meta-Analysis

23 citations , February 2017 in “Journal of dermatology”

This meta-analysis suggests that patients with alopecia areata have lower serum levels of zinc and selenium compared to healthy controls, which may be important risk factors for the condition.

research Assessment of Vitamin D Receptors in Alopecia Areata and Androgenetic Alopecia

20 citations , May 2016 in “Journal of Cosmetic Dermatology”

This study suggests that lower serum and tissue vitamin D receptor levels in alopecia areata and androgenetic alopecia patients may play a role in the pathogenesis of these hair diseases.

research Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

48 citations , May 2015 in “PLOS ONE”

This study found that a genetic test using 5 to 20 SNPs can predict male pattern baldness with variable accuracy in European men, especially those aged 50 and older.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Association of Premature Androgenetic Alopecia and Metabolic Syndrome in a Young Indian Population

16 citations , January 2014 in “International Journal of Trichology”

This study found that male Indian patients under 30 with early androgenetic alopecia were more likely to have metabolic syndrome compared to age-matched controls.

research Molecular Basis of Androgenetic Alopecia

11 citations , January 2010 in “Springer eBooks”

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

In this study, the researchers did not confirm previously reported links between AGA and smoking or benign prostatic hypertrophy, but found potential associations with alcohol consumption and lean body mass at age 21 that merit further investigation.