Sebaceous gland organoid engineering

    January 2024 in “ Burns & Trauma
    Yiqiong Liu, Huanhuan Gao, Chen Hua-ting, Shuaifei Ji, Lu Wu, Hongliang Zhang, Yujia Wang, Xiaobing Fu, Xiaoyan Sun
    TLDR Sebaceous gland organoids could improve skin regeneration and treatment.
    The document discusses recent advancements in sebaceous gland (SG) organoid engineering, highlighting their potential in regenerative medicine. SG organoids are 3D structures that mimic the characteristics of in vivo tissues and have shown promise in replicating the main features of natural SGs. Engineering approaches allow for manipulation of cell behaviors and environments, enhancing the functionality of SG organoids. The review outlines strategies for creating vascularized, innervated, immune-interactive, and lipogenic SG organoids, aiming to bridge the gap between laboratory research and clinical application, ultimately improving understanding of SG biology and regeneration.
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