Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain

    February 2017 in “Clinical Drug Investigation
    Ion G. Motofei, David L. Rowland, Mirela Manea, Simona Roxana Georgescu, Ioana Paunica, Ioanel Sinescu
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    TLDR Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.
    The paper discusses the safety profile of finasteride, a drug used to treat male pattern baldness. The most common adverse effects of finasteride are sexual dysfunction and depression, which often occur together and can persist even after treatment cessation, leading to a condition called post-finasteride syndrome. The paper suggests that understanding the variation of finasteride side effects among different populations would be necessary not only to delineate the safety profile of finasteride for different subgroups of men but also as a possible premise for a therapeutic approach of finasteride adverse effects. The authors propose that some patients who develop finasteride adverse effects may benefit from administration of hormonal drugs like dihydrotestosterone or dihydroprogesterone.
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