Research Progress in Regulation of Hair Growth by Dermal Adipose Tissue

May 2024 in “ PubMed ”

Yue Zhang, Wei Tang, Weidong Tian, Mei Yu

dermal adipose tissue hair growth hair cycle signaling molecules

TLDR Dermal fat helps control hair growth, but more research is needed.

Dermal adipose tissue plays a significant role in regulating hair growth and the transition of the hair cycle by secreting various signaling molecules. Despite its importance, the current literature is insufficient to fully understand its role, and further research is needed to explore the specific regulatory mechanisms involved.

View this study on pmc.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

21 / 21 results

research Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche

74 citations , October 2023 in “Nature Reviews Molecular Cell Biology”

Exploring The Effects Of Wetting And Free Fatty Acid Deposition On An Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

research Exploring The Effects Of Wetting And Free Fatty Acid Deposition On An Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

1 citations , April 2023 in “Langmuir”

Damaged hair allows water to penetrate more easily, and fatty acids from shampoos can deposit on hair surfaces.

research Growth Hormone and the Human Hair Follicle

14 citations , December 2021 in “International journal of molecular sciences”

Growth hormone levels affect hair growth and loss, with too much causing excess hair and too little leading to hair loss.

research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

research Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration

19 citations , June 2021 in “Tissue Engineering and Regenerative Medicine”

Fat stem cell particles help regrow hair.

research Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

29 citations , January 2021 in “Journal of Investigative Dermatology”

Fat under the skin releases HGF which helps hair grow and gain color.

research The Role of Immature and Mature Adipocytes in Hair Cycling

30 citations , December 2018 in “Trends in Endocrinology and Metabolism”

Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Emerging Nonmetabolic Functions of Skin Fat

65 citations , January 2018 in “Nature Reviews Endocrinology”

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations , November 2017 in “Journal of developmental biology”

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , January 2017 in “Science”

Some wound-healing cells can turn into fat cells around new hair growth in mice.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis

106 citations , October 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

research Telogen Elongation in the Hair Cycle of ob/ob Mice

5 citations , August 2015 in “Bioscience, Biotechnology, and Biochemistry”

Obese mice with a leptin gene mutation have a longer resting phase in their hair cycle, which may help understand certain hair loss conditions.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.

research Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior

42 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.

research Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation

176 citations , January 2013 in “Proceedings of the National Academy of Sciences”

BMP and Wnt signaling balance controls hair follicle stem cell activity and hair growth.

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

77 citations , July 2012 in “Journal of Investigative Dermatology”

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.