Exploring The Effects Of Wetting And Free Fatty Acid Deposition On An Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

April 2023 in “ Langmuir ”

Jeffrey M. Sanders, Benjamin J. Coscia, Alexandr Fonari, Mayank Misra, Paulo G. M. Mileo, David J. Giesen, Andrea Browning, Mathew D. Halls

wetting free fatty acid FFA hair fiber Keratin-Associated Protein 5-1 hair damage virgin hair light damage moderate damage lattice dimensions structural properties water free fatty acids hair health hair appearance

TLDR Damaged hair allows water to penetrate more easily, and fatty acids from shampoos can deposit on hair surfaces.

The study investigates the effects of wetting and free fatty acid (FFA) deposition on a detailed atomistic model of hair fibers that includes Keratin-Associated Protein 5-1. The research examines different conditions of hair damage (virgin, light damage, moderate damage) and their impact on the hair fiber's structural properties. The findings indicate that both wetting and FFA deposition significantly alter the lattice dimensions of the hair fiber model, with more pronounced changes observed in damaged hair. This suggests that the presence of water and FFAs can affect the physical properties of hair, potentially influencing its overall health and appearance.

View this study on pubs.acs.org →

Discuss this study in the Community →

Research cited in this study

17 / 17 results

research Discrete Nanoscale Distribution of Hair Lipids Fails to Provide Humidity Resistance

15 citations , August 2020 in “Analytical chemistry”

Hair lipids do not protect against humidity.

research Prevention of Lipid Loss from Hair by Surface and Internal Modification

17 citations , July 2019 in “Scientific reports”

Surface and internal treatments can help prevent hair lipid loss during washing.

research Degradation of Hair Surface: Importance of 18-MEA and Epicuticle

25 citations , May 2019 in “Cosmetics”

18-MEA and cationic surfactants can restore and maintain hair's hydrophobic nature, improving its beauty and feel.

research Morphology and Properties of Hair

3 citations , December 2018 in “Routledge eBooks”

Hair is made of strong keratin fibers that protect against the environment.

research Molecular Modeling and Structural Characterization of a High Glycine–Tyrosine Hair Keratin Associated Protein

16 citations , January 2017 in “Physical chemistry chemical physics/PCCP. Physical chemistry chemical physics”

The 3D structure of a key hair protein was modeled, revealing specific helical structures and stabilization features.

research Distribution and Localization of Hydrophobic and Ionic Chemical Groups at the Surface of Bleached Human Hair Fibers

36 citations , October 2014 in “Langmuir”

Bleaching hair removes its protective top layer and exposes more hydrophilic groups, changing its chemical surface and affecting how it interacts with products.

research The Physical Properties of Hair Fibers

7 citations , December 2011 in “Springer eBooks”

I'm sorry, but I can't provide a summary without the content of the document.

research ToF-SIMS Characterization of the Lipid Layer on the Hair Surface: Effect of the 18-MEA Lipid Layer on Surface Hydrophobicity

19 citations , May 2010 in “Surface and interface analysis”

18-MEA is essential for hair's water resistance, and a conditioner with 18-MEA and SPDA can restore it.

research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

Keratin from hair and wool is used in medical materials for healing and drug delivery.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Human Hair Keratin-Associated Proteins

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

research A Systematic Method for the Sensitive and Specific Determination of Hair Lipids Using Chromatography

43 citations , July 2005 in “Journal of Chromatography B”

A new method accurately measures hair lipids, revealing individual differences.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Hair Follicle Differentiation And Regulation

199 citations , January 2004 in “The International Journal of Developmental Biology”

Hair follicle growth and development are controlled by specific genes and molecular signals.

research Ultrastructural Localization of S100A3, a Cysteine-Rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-Freezing Immunocytochemistry

40 citations , April 1999 in “Journal of Histochemistry & Cytochemistry”

S100A3 protein is mainly found in specific parts of human hair cells.

research The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair

228 citations , January 1997 in “Birkhäuser Basel eBooks”

Keratin proteins and their genes are crucial for hair growth and structure.

research Sequence, Expression, and Evolutionary Conservation of a Gene Encoding a Glycine/Tyrosine-Rich Keratin-Associated Protein of Hair

76 citations , February 1993 in “Journal of Biological Chemistry”

KAP6 genes are conserved across species and active in hair follicles.

Similar Research

5 / 261 results

Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

research Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

November 2022

Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.

research Exogenous and Endogenous Lipids of Human Hair

21 citations , March 2017 in “Skin research and technology”

Removing external lipids from hair reduces moisture and increases strength, while removing internal lipids decreases water permeability.

research External Lipid Function in Ethnic Hairs

7 citations , March 2019 in “Journal of cosmetic dermatology”

African hair has the most lipids, while Caucasian hair is more hydrated and stronger.

research Discrete Nanoscale Distribution of Hair Lipids Fails to Provide Humidity Resistance

15 citations , August 2020 in “Analytical chemistry”

Hair lipids do not protect against humidity.

research Modulating Metal-Organic Frameworks by Surface Engineering of Stearic Acid Modification for Follicular Drug Delivery and Enhanced Hair Growth Promotion

2 citations , February 2025 in “Journal of Nanobiotechnology”

Modified frameworks with stearic acid enhance drug delivery and promote hair growth.

Exploring The Effects Of Wetting And Free Fatty Acid Deposition On An Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

Research cited in this study

research Discrete Nanoscale Distribution of Hair Lipids Fails to Provide Humidity Resistance

research Prevention of Lipid Loss from Hair by Surface and Internal Modification

research Degradation of Hair Surface: Importance of 18-MEA and Epicuticle

research Morphology and Properties of Hair

research Molecular Modeling and Structural Characterization of a High Glycine–Tyrosine Hair Keratin Associated Protein

research Distribution and Localization of Hydrophobic and Ionic Chemical Groups at the Surface of Bleached Human Hair Fibers

research The Physical Properties of Hair Fibers

research ToF-SIMS Characterization of the Lipid Layer on the Hair Surface: Effect of the 18-MEA Lipid Layer on Surface Hydrophobicity

research A Review of Keratin-Based Biomaterials for Biomedical Applications

research Biology of the Hair Follicle: The Basics

research Human Hair Keratin-Associated Proteins

research A Systematic Method for the Sensitive and Specific Determination of Hair Lipids Using Chromatography

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Follicle Differentiation And Regulation

research Ultrastructural Localization of S100A3, a Cysteine-Rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-Freezing Immunocytochemistry

research The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair

research Sequence, Expression, and Evolutionary Conservation of a Gene Encoding a Glycine/Tyrosine-Rich Keratin-Associated Protein of Hair

Related Community Posts Join

community We cooked fam? 1 Year on Dut + Oral Min after years of Fin (some mistakes made & details in comments)

community 2 months and half progress. Just take the f*cking pill. (Completely wet hair)

community Showerthought: Having a Chia pet as a kid really helped me with using the "Big 3" as an adult

community Yesterday was my first haircut in 5 years where I couldn’t see my scalp under the barbers lights.

community CURLY HAIR HELP: Some questions about scalp buildup from topical minox

community I want my hair back so badly bros

Similar Research

research Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

research Exogenous and Endogenous Lipids of Human Hair

research External Lipid Function in Ethnic Hairs

research Discrete Nanoscale Distribution of Hair Lipids Fails to Provide Humidity Resistance

research Modulating Metal-Organic Frameworks by Surface Engineering of Stearic Acid Modification for Follicular Drug Delivery and Enhanced Hair Growth Promotion