Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway
February 2022
in “Journal of Dermatological Treatment”
TLDR Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.
This study evaluated the efficacy of electrodynamic microneedling combined with 5% minoxidil in treating androgenetic alopecia (AGA) in Chinese male patients and explored the underlying mechanisms. The study involved 71 male volunteers with AGA who completed the entire trial and follow-up. The combination therapy showed superior therapeutic effects clinically, with further upregulation of FZD3, ß-catenin, and LEF-1 expression levels at both mRNA and protein levels in the treated areas. The study concluded that microneedling combined with 5% minoxidil can improve AGA, and the underlying mechanism may involve activation of the Wnt/ß-catenin signaling pathway.
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