Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks
November 2022
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
Hidradenitis Suppurativa hair follicle epithelial stem cells keratin plug induced pluripotent stem cells NCSTN gene CRISPR-Cas9 RNA-seq keratinocyte proliferation keratinocyte differentiation cytokine genes chemokine genes IL1a IL18 CCL20 S100A7 neutrophils Th17 cells 3D-imaging hair follicles inflammatory proteins HS iPSCs CRISPR RNA sequencing interleukin-1 alpha interleukin-18 chemokine ligand 20 psoriasin
Studysummary This study found that skin organoids derived from iPSCs with an HS-associated NCSTN mutation showed defects in hair follicle stem cell differentiation and increased expression of inflammatory proteins related to hidradenitis suppurativa.
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