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GlossaryInterleukin-1 alpha (IL1A)

promotes inflammation and influences hair follicle biology

Interleukin-1 alpha (IL-1α) is a type of protein known as a cytokine, which plays a crucial role in the body's immune response by promoting inflammation. It is involved in various cellular activities, including cell proliferation, differentiation, and apoptosis. In the context of hair and alopecia, IL-1α can influence hair follicle biology and has been implicated in inflammatory conditions that may lead to hair loss.

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research A Functional Polymorphism in Interleukin-1α (IL1A) Gene Is Associated with Risk of Alopecia Areata in Chinese Populations

11 citations, March 2013 in “Gene”

A certain genetic variation in the IL1A gene may lower the risk of a hair loss condition in Chinese people.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

June 2023 in “Cells”

The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.

research CDK9 Kinase Activation in Association with AFF1-SEC Initiates Epidermal Progenitor Differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research Skin Involvement in Systemic Lupus Erythematosus: A Review Article

March 2023 in “Revista română de reumatologie”

Skin problems are common in lupus, often appearing first, with various types and treatments, and careful monitoring is important for diagnosis and management.

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