Paradoxical Alopecia Areata Induced by IL-17 and IL-23 Inhibitors: A Systematic Review

    June 2026 in “ JEADV Clinical Practice ”
    Isabella Kamholtz, Simonetta I. Gaumond, JJ Jimenez
    Studysummary This review synthesizes cases of biopsy-confirmed alopecia areata occurring in patients using IL-17 or IL-23 inhibitors, suggesting the need for increased awareness and further investigation into this rare adverse event.
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    Research cited in this study 19

    1. Alopecia Areata Associated With Dupilumab: National Database Study Diagnostics · 2025
    2. Disruption of Hair Follicle Immune Privilege in Alopecia Areata: Enigmatic Mechanisms and Emerging Concepts Academic Medical Journal · 2025
    3. Tumor Necrosis Factor α Inhibitor-Induced Alopecia in Pediatric Patients: A Cohort of 20 Patients and Review of the Literature Archives of Dermatological Research · 2025
    4. Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events Biologics · 2025
    5. Alopecia Areata Following COVID-19 Vaccine: A Systematic Review European journal of medical research · 2024
    6. Ophiasis Alopecia Areata in a Patient With Spondyloarthritis on Secukinumab: A Case Report and Review of the Literature Curēus · 2024
    7. Secukinumab-Induced Alopecia Areata Successfully Treated with Tofacitinib in a Patient with Palmoplantar Pustulosis Clinical, cosmetic and investigational dermatology · 2023
    8. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    9. Drug-Induced Alopecia Areata: A Systematic Review Journal of the American Academy of Dermatology · 2023
    10. Alopecia Areata After Initiation of Secukinumab Therapy for Plaque Psoriasis Cureus · 2023
    11. New Onset Alopecia Areata During Secukinumab Therapy Dermatologic Therapy · 2019
    12. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    13. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    14. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    15. Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors British journal of dermatology/British journal of dermatology, Supplement · 2016
    16. Alopecia Areata: What’s New in Epidemiology, Pathogenesis, Diagnosis, and Therapeutic Options? Journal of dermatological science · 2016
    17. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
    18. Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy Anais Brasileiros de Dermatologia · 2015
    19. Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis Journal of dermatology · 2003