Tumor Necrosis Factor α Inhibitor-Induced Alopecia in Pediatric Patients: A Cohort of 20 Patients and Review of the Literature

    June 2025 in “ Archives of Dermatological Research ”
    Shiran Reiss‐Huss, Daniel Hilewitz, Sharon Yacobovitz … Rivka Friedland
    Studysummary In a retrospective study, TNFα inhibitor-induced alopecia was observed in pediatric patients, primarily adolescents with inflammatory bowel diseases, with hair regrowth occurring in those who discontinued the therapy; this suggests that stopping these medications can improve drug-induced alopecia in children.
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    Research cited in this study 10

    1. Risk Factors for the Development of and Outcomes After Diagnosis of Autoimmune Alopecia Areata in Patients with Inflammatory Bowel Diseases Digestive Diseases and Sciences · 2024
    2. A Cross-Sectional Analysis of Medications Used by Patients Reporting Alopecia Areata on the FDA Adverse Events Reporting System International Journal of Dermatology · 2024
    3. Psoriatic Alopecia in a Patient With Crohn's Disease: An Uncommon Manifestation of Tumor Necrosis Factor Alpha Inhibitors Cutis · 2021
    4. Psoriatic Alopecia Clinical and Experimental Dermatology · 2015
    5. Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy Anais Brasileiros de Dermatologia · 2015
    6. Adalimumab-Induced Psoriatic Alopecia/Alopecia Areata-Like Reaction in a Patient with Crohn's Disease Dermatology Online Journal · 2015
    7. Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database Rheumatology · 2014
    8. Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature Dermatology · 2012
    9. Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia The American Journal of Dermatopathology · 2011
    10. Alopecia Areata as Another Immune-Mediated Disease Developed in Patients Treated with Tumor Necrosis Factor-Alpha Blocker Agents Journal of the European Academy of Dermatology and Venereology · 2010