Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature

January 2012 in “ Dermatology ”

Fernando Osório, Fernando Magro, Cármen Lisboa, Susana Lopes, Guilherme Macedo, Herberto Bettencourt, Filomena Azevedo, Sofia Magina

anti-TNF-α psoriasiform eruptions scalp involvement inflammatory alopecia topical therapy systemic therapy methotrexate cyclosporine scarring alopecia anti-TNF-alpha psoriasis-like eruptions scalp issues hair loss topical treatment systemic treatment MTX CsA permanent hair loss

TLDR Severe anti-TNF-α induced scalp eruptions often need stopping the drug and using systemic therapy to avoid scarring.

The document reported on five cases of psoriasiform eruptions with severe scalp involvement and alopecia induced by anti-TNF-alpha therapy. The study highlighted the adverse effects of anti-TNF-alpha treatments, which are commonly used for conditions like rheumatoid arthritis and Crohn's disease. The patients experienced significant hair loss and scalp issues, which were notable side effects. The review of the literature suggested that while these reactions were rare, they were important for clinicians to recognize and manage appropriately.

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