Secukinumab-Induced Alopecia Areata Successfully Treated with Tofacitinib in a Patient with Palmoplantar Pustulosis
October 2023
in “
Clinical, cosmetic and investigational dermatology
”
![Image of study](/images/research/63813371-49e4-4dfc-adf0-40b47638d030/medium/26834.jpg)
TLDR Tofacitinib improved hair loss and skin symptoms in a patient after secukinumab caused hair loss.
A 35-year-old female patient with Palmoplantar Pustulosis (PPP) developed Alopecia Areata (AA), a rare side effect, after treatment with secukinumab, a drug that targets interleukin-17 (IL-17). After discontinuing secukinumab and starting treatment with tofacitinib, both her AA and PPP significantly improved. The study suggests that tofacitinib could be a potential treatment for AA induced by biologics during PPP treatment. However, more research with larger sample sizes is needed to confirm these findings.