Secukinumab-Induced Alopecia Areata Successfully Treated with Tofacitinib in a Patient with Palmoplantar Pustulosis

    October 2023 in “ Clinical, cosmetic and investigational dermatology ”
    Chen Zhang, Tianlun Kang, Tangliang Qian … Chen Li
    Studysummary In this report, a 35-year-old female with palmoplantar pustulosis undergoing secukinumab treatment developed alopecia areata, a rare side effect attributed to paradoxical reactions with IL-17 inhibitors; switching to tofacitinib improved both conditions.
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    Research cited in this study 3

    1. IL-17 Inhibition: Is It the Long-Awaited Savior for Alopecia Areata? Archives of Dermatological Research · 2018
    2. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    3. Alopecia Areata as Another Immune-Mediated Disease Developed in Patients Treated with Tumor Necrosis Factor-Alpha Blocker Agents Journal of the European Academy of Dermatology and Venereology · 2010

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