Changes in Oxidative Stress Indicators with Topical Minoxidil in Chemically Depilated Rats

September 2023 in “ Pharmacology and Drug Toxicology ”

О. Є. Балюк, О. М. Важнича, Р. В. Луценко, V.О. Kostenko, О. Є. Акімов

minoxidil oxidative stress malondialdehyde superoxide dismutase hair regrowth antioxidant effect chemically induced depilation Rogaine

Studysummary In this study with hair-loss-induced rats, topical minoxidil treatment was found to have antioxidant effects in the skin and blood, decreasing oxidative stress markers over a 21-day period, without showing significant hair growth improvement compared to the control group.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study investigated the effects of topical minoxidil on oxidative stress markers during hair regeneration in 35 male rats with chemically induced depilation. Minoxidil treatment was applied daily, and hair regrowth was assessed at 3, 9, and 21 days. Results showed that minoxidil reduced malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) activity in both skin and blood, indicating an antioxidant effect. Hair regrowth was significantly improved by day 21, although differences with the control were not statistically significant. The findings suggest that minoxidil's antioxidant properties could be beneficial in clinical settings involving oxidative stress.

View this study on pharmtox-j.org.ua →

Discuss this study in the Community →

Research cited in this study

23 / 23 results

research Effects of Depilatory Cream Formulation and Contact Time on Mouse Skin

5 citations , March 2023 in “Journal of the American Association for Laboratory Animal Science”

In this study, the researchers observed that both standard body and facial depilatory creams caused significant skin injury in mice, with varying effects depending on the mouse strain and exposure time, although both formulations were effective for hair removal.

research Advances in Hair Growth

1 citations , January 2022 in “Faculty reviews”

This review discusses recent advances in understanding hair growth mechanisms and reviews current and emerging therapies, but it presents no new clinical results.

research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

17 citations , November 2021 in “Journal of Cosmetic Dermatology”

This review discusses treatment options for androgenetic alopecia, highlighting the need for personalized, evidence-based approaches but reports no new clinical results.

research Microneedling in Androgenetic Alopecia: Comparing Two Different Depths of Microneedles

10 citations , September 2020 in “Journal of Cosmetic Dermatology”

In this study, microneedling with a depth of 0.6 mm, alongside minoxidil, significantly improved hair count and thickness in patients with androgenetic alopecia compared to minoxidil alone, and was more beneficial than a 1.2 mm depth.

research Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia

14 citations , September 2020 in “Dermatologic Therapy”

This study reported that oral minoxidil improved hair density and had an acceptable safety profile in women with androgenetic alopecia.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations , February 2020 in “Expert Opinion on Pharmacotherapy”

This review discusses pharmacologic and non-pharmacologic treatments for androgenetic alopecia, noting that current medications like finasteride and minoxidil can slow hair loss but only partially restore hair growth, with early treatment offering better outcomes.

research Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology”

This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.

research Types and Treatment of Hair Loss in Men and Women

8 citations , January 2020 in “Plastic and Aesthetic Nursing”

This article reviews management strategies and interventions for common hair loss disorders in men and women, highlighting the psychological impact and emphasizing gender-specific approaches, but reports no new clinical results.

research Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review

11 citations , December 2019 in “Dermatologic Therapy”

This systematic review suggests that topical ketoconazole may improve hair regrowth and thickness in both animal and human studies for androgenetic alopecia, but further randomized controlled trials are needed.

Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

research Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

14 citations , August 2019 in “Journal of Dermatological Treatment”

This study found that 5% topical minoxidil was moderately more effective at increasing hair regrowth than 10% minoxidil and placebo in men with androgenetic alopecia.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.

research Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review

11 citations , March 2019 in “Journal of The American Academy of Dermatology”

This review identifies evidence of sexual adverse effects, particularly linked to finasteride, in men using systemic dermatologic medications but reports no new clinical findings.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , August 2018 in “Skin appendage disorders”

This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.

research Evaluation of Animal Models Suitable for Hair Research and Regeneration

3 citations , May 2018 in “InTech eBooks”

This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.

research Review of Quality of Life Studies in Women with Alopecia

58 citations , January 2018 in “International Journal of Women's Dermatology”

This review discusses the psychological impact of alopecia on women and reports no new clinical findings, highlighting the effect on self-esteem and quality of life.

research Platelet-Rich Plasma for Androgenic Alopecia Treatment: A Comprehensive Review

16 citations , January 2018 in “Dermatology Online Journal”

This review discusses platelet-rich plasma treatment for androgenic alopecia, summarizing current understanding of the disease and the need for standardized clinical trials, but it reports no new results.

research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

22 citations , December 2017 in “International Journal of Molecular Sciences”

This study found that millimolar concentrations of minoxidil in the skin induced VEGF production through HIF-1 stabilization by inhibiting PHD-2, implying a molecular mechanism for hair growth promotion.

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

58 citations , October 2016 in “Journal of Investigative Dermatology”

This study found that activating Nrf2 in human hair follicles significantly reduced oxidative stress, lipid peroxidation, and protected against hair growth inhibition, suggesting a protective role for Nrf2 against redox insult in this context.

research Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model

3 citations , January 2016 in “Annals of Dermatology”

This study suggests that 2% minoxidil and Kerium may promote hair regrowth in rats, while Aminexil showed the least effect among tested treatments; human-use products varied in efficacy in this animal model.

research Hair Loss And Regeneration Performed On Animal Models

17 citations , October 2015 in “Medicine and Pharmacy Reports”

This article reviews current research on animal models for hair regrowth treatments and reports no new findings; it highlights the need for studies comparing therapy efficiency and long-term safety.

research Low-Level Laser Therapy for Treatment of Hair Loss

165 citations , August 2013 in “Lasers in Surgery and Medicine”

This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.

Effects of Topical Application of Growth Factors Followed by Microneedle Therapy in Women with Female Pattern Hair Loss: A Pilot Study

research Effects of Topical Application of Growth Factors Followed by Microneedle Therapy in Women with Female Pattern Hair Loss: A Pilot Study

34 citations , October 2012 in “Journal of Dermatology”

This pilot study suggests that using growth factors followed by microneedle therapy may benefit women with female pattern hair loss.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations , August 2011 in “Journal of The American Academy of Dermatology”

In this study, latanoprost significantly increased hair density in young men with mild androgenetic alopecia after 24 weeks, suggesting it may stimulate hair follicle activity and treat hair loss.