Changes in Oxidative Stress Indicators with Topical Minoxidil in Chemically Depilated Rats

September 2023 in “ Pharmacology and Drug Toxicology ”

О. Є. Балюк, О. М. Важнича, Р. В. Луценко, V.О. Kostenko, О. Є. Акімов

minoxidil oxidative stress malondialdehyde superoxide dismutase hair regrowth antioxidant effect chemically induced depilation Rogaine

TLDR Minoxidil reduces oxidative stress and helps hair regrowth.

This study investigated the effects of topical minoxidil on oxidative stress markers during hair regeneration in 35 male rats with chemically induced depilation. Minoxidil treatment was applied daily, and hair regrowth was assessed at 3, 9, and 21 days. Results showed that minoxidil reduced malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) activity in both skin and blood, indicating an antioxidant effect. Hair regrowth was significantly improved by day 21, although differences with the control were not statistically significant. The findings suggest that minoxidil's antioxidant properties could be beneficial in clinical settings involving oxidative stress.

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