Systematic Review of Oral Janus Kinase Inhibitors in Alopecia Areata: Insights from 2020 to 2025 Studies

    Anna Mandecka, Kornela Kotucha-Cyl, Weronika Komala … Marta Nowocień
    Studysummary This systematic review concluded that oral JAK inhibitors, such as baricitinib and deuruxolitinib, are effective and generally well-tolerated treatments for moderate-to-severe alopecia areata, offering advantages over traditional therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 24

    1. Local Corticosteroids for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    2. Comparison of Efficacy of Baricitinib Versus Methotrexate Therapy in the Treatment of Severe Alopecia Areata 2025
    3. The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta-Analysis Study Journal of Cosmetic Dermatology · 2025
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    5. Baricitinib for the Treatment of Severe Alopecia Areata: Results from a 52-Week Multicenter Retrospective Real-World Study Journal of Dermatological Treatment · 2025
    6. Comparative Efficacy and Safety of Baricitinib Against Traditional Therapies in Severe Alopecia Areata: A Retrospective Cohort Study Journal of Cosmetic Dermatology · 2024
    7. Efficacy and Safety of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, in Adolescent and Adult Patients with Alopecia Totalis and Alopecia Universalis The Journal of Dermatology · 2024
    8. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    9. Long-Term Efficacy and Safety of Baricitinib in Patients With Severe Alopecia Areata: 104-Week Results From BRAVE-AA1 and BRAVE-AA2 Journal of the European Academy of Dermatology and Venereology · 2024
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