Systematic Review of Oral Janus Kinase Inhibitors in Alopecia Areata: Insights from 2020 to 2025 Studies

December 2025 in “ International Journal of Innovative Technologies in Social Science ”

Anna Mandecka, Kornela Kotucha-Cyl, Weronika Komala, Natalia Guzik, Joanna Gerlach, Dorota Plechawska, Joanna Kaźmierczak, Karolina Witek, Marta Nowocień

Janus kinase inhibitors alopecia areata baricitinib deuruxolitinib Severity of Alopecia Tool SALT score JAK inhibitors AA

TLDR Oral JAK inhibitors effectively treat alopecia areata and are generally well-tolerated.

The systematic review of studies from 2020 to 2025 on oral Janus kinase (JAK) inhibitors for alopecia areata reveals their promising efficacy and safety, particularly highlighting baricitinib, ritlecitinib, and deuruxolitinib as effective treatments for severe cases. Significant hair regrowth and manageable side effects were observed, with a notable phase 3 trial of deuruxolitinib showing positive results in adults. The review emphasizes the potential of JAK inhibitors as a viable treatment option, providing new hope for patients with alopecia areata.

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