Comparison of Efficacy of Baricitinib Versus Methotrexate Therapy in the Treatment of Severe Alopecia Areata

April 2025

Pranam Swapan Dash, Lubna Khondker, Muhammad Aamir Khan, M S I Talukder, S Jahan, Esrat Khan Lubna

baricitinib methotrexate alopecia areata Severity of Alopecia Tool SALT90

TLDR Baricitinib works better than methotrexate for severe alopecia areata.

This randomized controlled trial compared the efficacy of baricitinib and methotrexate in treating severe alopecia areata in 84 patients. Patients were divided into two groups, with group A receiving baricitinib and group B receiving methotrexate. Over 6 months, group A showed significantly greater improvement in the Severity of Alopecia Tool (SALT) scores compared to group B. At month 6, 57.1% of patients in group A achieved a complete response (SALT90), while none in group B did. The study concludes that baricitinib is superior to methotrexate for treating severe alopecia areata, suggesting it as an excellent choice for patients with extensive disease, though further research is needed to evaluate long-term efficacy.

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community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

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After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

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community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

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