Comparison of Efficacy of Baricitinib Versus Methotrexate Therapy in the Treatment of Severe Alopecia Areata

April 2025

Pranam Swapan Dash, Lubna Khondker, Muhammad Aamir Khan, M S I Talukder, S Jahan, Esrat Khan Lubna

baricitinib methotrexate alopecia areata Severity of Alopecia Tool SALT90

This randomized controlled trial compared the efficacy of baricitinib and methotrexate in treating severe alopecia areata in 84 patients. Patients were divided into two groups, with group A receiving baricitinib and group B receiving methotrexate. Over 6 months, group A showed significantly greater improvement in the Severity of Alopecia Tool (SALT) scores compared to group B. At month 6, 57.1% of patients in group A achieved a complete response (SALT90), while none in group B did. The study concludes that baricitinib is superior to methotrexate for treating severe alopecia areata, suggesting it as an excellent choice for patients with extensive disease, though further research is needed to evaluate long-term efficacy.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 15 results

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 3 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 2 years ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 3 years ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community Lilly to seek first approval of an autoimmune drug for hair loss

in Research/Science 19 upvotes 4 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community Does a minoxidil tester exist? To test if whatever you get is actually minoxidil or some fake?

in Minoxidil 1 year ago

The conversation discusses the uncertainty of the legitimacy of minoxidil products in the EU market and mentions baricitinib as an approved, but expensive alternative. A method to test for real minoxidil involves mixing it with bleach to see if it turns orange or brown.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.