Comparative Efficacy and Safety of Baricitinib Against Traditional Therapies in Severe Alopecia Areata: A Retrospective Cohort Study

    November 2024 in “ Journal of Cosmetic Dermatology
    Athanasios J. Stefanis, Tomáš Doležal, Spyridon Gkalpakiotis, Petr Arenberger
    TLDR Baricitinib is effective for severe alopecia areata but has some side effects.
    This retrospective cohort study evaluated the efficacy and safety of baricitinib, a JAK inhibitor, compared to traditional therapies for severe alopecia areata (AA) over 6 months, involving 75 patients. Baricitinib showed promising results, with a significant number of patients achieving a SALT score ≤20, indicating ≤20% scalp hair loss, and outperforming other therapies in hair regrowth. Approximately 30% of baricitinib patients achieved a SALT score ≤20, and nearly 50% reached SALT50, with 26% achieving SALT90. However, baricitinib was associated with adverse effects, including serum lipid elevations in nearly 50% of patients and short-lasting infections in 25%. The study supports baricitinib as a viable treatment for severe AA, though further research is needed to confirm these findings.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 11 results

    Related Research

    4 / 4 results