Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum Forskahlii Seed Oil via Network Pharmacology

    December 2025 in “ International Journal of Molecular Sciences ”
    Shaimaa R. Ahmed, Hanan Khojah, Maram Aldera … Sumera Qasim
    Studysummary In this study, O. forskahlii seed oil was found to promote hair growth in rats and exhibit anti-aging effects on human skin cells by enhancing fibroblast proliferation and inhibiting inflammation and enzyme activity, indicating potential for cosmetic use.
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    Research cited in this study 9

    1. The Role of Linoleic Acid in Skin and Hair Health: A Review International Journal of Molecular Sciences · 2024
    2. Effects of Nannochloropsis Salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth International Journal of Molecular Sciences · 2024
    3. Optimized Depilation Method and Comparative Analysis of Hair Growth Cycle in Mouse Strains Animals · 2024
    4. Millet Seed Oil Activates Beta-Catenin Signaling and Promotes Hair Growth Frontiers in Pharmacology · 2023
    5. Activation of Hair Cell Growth Factors by Linoleic Acid in Malva Verticillata Seed Molecules/Molecules online/Molecules annual · 2021
    6. Study on the Chemical Constituents of Nut Oil from Prunus Mira Koehne and the Mechanism of Promoting Hair Growth Journal of ethnopharmacology · 2020
    7. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    8. Interleukin 6 Induces the Hair Follicle Growth Phase (Anagen) Journal of Dermatological Science · 2006
    9. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996