Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

The study investigated bioactive metabolites from three Polynesian plants—Bidens pilosa, Calophyllum inophyllum, and Fagraea berteroana—targeting dermal papilla cells involved in the hair cycle. Using Feature-Based Molecular Networking, the researchers identified compounds that correlated with DPC proliferation, a key factor in hair growth. Notably, corosolic acid from F. berteroana was highlighted for its potential role in promoting hair growth by increasing β-catenin levels, crucial for the anagen phase of the hair cycle. The study provided insights into the chemical composition of these plants and their potential use in hair care products, although it did not specify the number of participants or direct clinical outcomes.