Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

The study investigated the bioactive metabolites from three plants traditionally used in French Polynesia for hair care: Bidens pilosa, Calophyllum inophyllum, and Fagraea berteroana. Using LC-MS/MS data and Pearson correlation, the research identified glycosylated flavonols and phenolic acids from B. pilosa and C. inophyllum, as well as C-flavonoids, iridoids, and secoiridoids from F. berteroana, as potential molecules promoting dermal papilla cell proliferation, which is crucial for hair follicle growth. The findings supported the traditional use of these plants in promoting hair growth.