Interleukin 6 Induces the Hair Follicle Growth Phase (Anagen)

June 2006 in “ Journal of Dermatological Science ”

Atsuko Tanabe, Yutaka Ogawa, Takashi Takemoto, Yibiao Wang, Takako Furukawa, Hirao Kono, Yasushi Adachi, Kenji Kusumoto

interleukin 6 IL-6 anagen hair follicle cytokines bFGF TGFα FGF TGFβ IGF-1 NGF PDGF VEGF alopecia hair regeneration hair growth phase growth factors wound healing

TLDR Interleukin 6 helps hair grow.

The document discussed the role of interleukin 6 (IL-6) in promoting the hair follicle growth phase, known as anagen. It was observed that hair growth was promoted in the skin adjacent to free skin grafts in rabbits, suggesting that wound healing-related factors, including cytokines like IL-6, might stimulate hair growth. The study highlighted the importance of IL-6 in the skin wound-healing process, as evidenced by delayed wound healing in IL-6-deficient mice. Various growth factors such as bFGF, TGFα, FGF, TGFβ, IGF-1, NGF, PDGF, and VEGF were also investigated for their roles in hair growth. The findings suggested that cytokines and growth factors could be potential targets for therapies aimed at treating alopecia and promoting hair regeneration.

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