Male androgenetic alopecia
May 2010
in “Expert Opinion on Pharmacotherapy”
TLDR Hair loss in men treated best with early medication or transplant, new treatments researched.
This document discusses male androgenetic alopecia (MAA), a genetic condition that causes hair loss in men. It affects up to 80% of males by the age of 80 and causes reduced self-esteem, loss of confidence, and anxiety in affected men. Hair transplant remains the only viable treatment for advanced hair loss, but newer agents such as prostaglandin analogues, gene therapy, and angiogenic growth factors are targets for future research. Effective and safe medications are available for the treatment of androgenetic alopecia, including topical minoxidil and finasteride tablets, which are FDA approved for the treatment of hair loss. Early treatment achieves the best results.
View this study on tandfonline.com →
Cited in this study
research Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss
Aromatase gene variation may increase female hair loss risk.
research The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit
Ludwig pattern hair loss in women results from varying sensitivity in hair follicles, causing fewer visible hairs.
research Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26
Hair loss gene found on chromosome 3q26.
research Men with Kennedy disease have a reduced risk of androgenetic alopecia
Men with Kennedy disease have less chance of hair loss.
research A new classification of pattern hair loss that is universal for men and women: Basic and specific (BASP) classification
The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.
research Dutasteride improves male pattern hair loss in a randomized study in identical twins
Dutasteride helps slow hair loss and boosts hair growth.
research Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial
Taking 1 mg/day finasteride for hair loss significantly lowers PSA levels in men, which may affect prostate cancer screening.
research The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride
Dutasteride more effective for hair growth, but has more side effects than finasteride.
research Finasteride induced depression: a prospective study
Finasteride may cause slight depression and anxiety.
research Prevalence of Male and Female Pattern Hair Loss in Maryborough
Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.
research Effects of Finasteride (1 mg) on Hair Transplant
Finasteride improves surrounding scalp hair and increases hair density after hair transplant.
research Treatment of female pattern hair loss with oral antiandrogens
Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.
research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia
Oral finasteride works better than topical minoxidil for hair growth, both are safe.
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research Perception of men with androgenetic alopecia by women and nonbalding men in Korea: how the nonbald regard the bald
Balding men seen as older, less attractive, and less confident.
research Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men
Best hair growth results from combining finasteride and minoxidil.
research Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial
Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.
research Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment
Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.
research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
research The genetics of androgenetic alopecia
Genes and hormones cause hair loss, with four genes contributing equally.
research Finasteride increases anagen hair in men with androgenetic alopecia
Finasteride helps increase hair growth in men with hair loss.
research Finasteride in the treatment of men with androgenetic alopecia
Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells
Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research The psychological effects of androgenetic alopecia in men
Hair loss can cause low self-esteem, anxiety, and depression in men.
research Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil
Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.
research Use of topical minoxidil as a possible adjunct to hair transplant surgery
Minoxidil may help hair growth after transplant surgery.
research Androgenetic alopecia: Treatment results with topical minoxidil
Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.
research Topical minoxidil in early androgenetic alopecia
Using minoxidil on balding scalps can stimulate hair regrowth and increase blood flow. It's an effective treatment for early hair loss.
research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography
Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.
research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs
Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.
research Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex
Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.
research Minoxidil therapy in children with severe hypertension
Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.
Related
research What's New in Therapy for Male Androgenetic Alopecia?
research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia
research Pharmacological therapeutics in androgenetic alopecia
research 한국인의 두피모발 특성과 남성형탈모증
The document's conclusion cannot be provided because the text is in Korean and cannot be parsed.
research Male androgenetic alopecia
Hair loss in men treated best with early medication or transplant, new treatments researched.
research Effective treatment of female androgenic alopecia with dutasteride.
Dutasteride successfully treated a woman's hair loss when other treatments failed.
research Therapy of alopecia
The document discussed the psychological impact of hair loss and its significance to the pharmaceutical and cosmetic industries. Androgenetic alopecia, responsible for 95% of hair loss, was primarily linked to aging, heredity, and testosterone levels. Key treatments included minoxidil, which promoted hair growth through vasodilatation, and finasteride, which inhibited the conversion of testosterone to dihydrotestosterone, preventing hair follicle miniaturization. Other substances like Saw palmetto, emu oil, vitamin B6, Polysorbate 80, retinoic acid, and azelaic acid were also noted for their potential benefits. Additionally, drugs with antiandrogen properties such as cyproterone, spironolactone, cimetidine, and ketoconazole, along with treatments involving zinc, unsaturated fatty acids, immunosuppressive drugs, irritants, and PUVA, were mentioned as useful in certain cases.
research Current management of androgenetic alopecia in men.
Minoxidil and finasteride are promising drugs that can prevent hair loss and promote new growth in people with common hair loss condition.
research CLINICAL UPDATES IN HAIR
Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.