Male Androgenetic Alopecia

May 2010 in “ Expert Opinion on Pharmacotherapy ”

Deepani Rathnayake, Rodney Sinclair

male androgenetic alopecia hair transplant prostaglandin analogues gene therapy angiogenic growth factors topical minoxidil finasteride tablets MAA Rogaine Propecia

TLDR Hair loss in men treated best with early medication or transplant, new treatments researched.

This document discusses male androgenetic alopecia (MAA), a genetic condition that causes hair loss in men. It affects up to 80% of males by the age of 80 and causes reduced self-esteem, loss of confidence, and anxiety in affected men. Hair transplant remains the only viable treatment for advanced hair loss, but newer agents such as prostaglandin analogues, gene therapy, and angiogenic growth factors are targets for future research. Effective and safe medications are available for the treatment of androgenetic alopecia, including topical minoxidil and finasteride tablets, which are FDA approved for the treatment of hair loss. Early treatment achieves the best results.

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77 citations , August 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

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47 citations , December 2008 in “British Journal of Dermatology”

Ludwig pattern hair loss in women results from varying sensitivity in hair follicles, causing fewer visible hairs.

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62 citations , March 2008 in “American Journal of Human Genetics”

Hair loss gene found on chromosome 3q26.

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Men with Kennedy disease have less chance of hair loss.

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The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.

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39 citations , March 2007 in “Journal of Cosmetic Dermatology”

Dutasteride helps slow hair loss and boosts hair growth.

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89 citations , January 2007 in “Lancet Oncology”

Taking 1 mg/day finasteride for hair loss significantly lowers PSA levels in men, which may affect prostate cancer screening.

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Finasteride may cause slight depression and anxiety.

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Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

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23 citations , October 2005 in “Dermatologic Surgery”

Finasteride improves surrounding scalp hair and increases hair density after hair transplant.

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Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.

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Oral finasteride works better than topical minoxidil for hair growth, both are safe.

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26 citations , December 2002 in “International Journal of Dermatology”

Balding men seen as older, less attractive, and less confident.

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80 citations , August 2002 in “Journal of Dermatology”

Best hair growth results from combining finasteride and minoxidil.

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123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

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83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

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Genes and hormones cause hair loss, with four genes contributing equally.

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Finasteride helps increase hair growth in men with hair loss.

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Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

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Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

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People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

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Hair loss can cause low self-esteem, anxiety, and depression in men.

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Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

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Minoxidil may help hair growth after transplant surgery.

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Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.

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9 / 9 results

research What's New in Therapy for Male Androgenetic Alopecia?

2 citations , September 2022 in “American Journal of Clinical Dermatology”

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

1 citations , August 2022 in “Journal of Dermatological Treatment”

research Pharmacological Therapeutics in Androgenetic Alopecia

3 citations , May 2020 in “Journal of The Korean Medical Association”

research Characteristics of Korean Scalp Hair and Male Pattern Baldness

January 2013 in “Journal of The Korean Medical Association”

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research Male Androgenetic Alopecia

100 citations , May 2010 in “Expert Opinion on Pharmacotherapy”

Hair loss in men treated best with early medication or transplant, new treatments researched.

research Effective Treatment of Female Androgenic Alopecia with Dutasteride

33 citations , September 2005 in “PubMed”

Dutasteride successfully treated a woman's hair loss when other treatments failed.

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January 2005 in “Farmaceutski glasnik”

Minoxidil and finasteride are key treatments for hair loss.

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4 citations , December 1999 in “PubMed”

Minoxidil and finasteride are promising drugs that can prevent hair loss and promote new growth in people with common hair loss condition.

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19 citations , January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.