Mechanisms of Autophagy and Their Implications in Dermatological Disorders

    November 2024 in “ Frontiers in Immunology ”
    Shibei Xue, Yumeng Lin, Haoran Chen … Ke Wang
    Studysummary This review examines the role of autophagy, specifically macrophage, chaperone-mediated, and microphagy, in the progression of six skin diseases, including psoriasis and systemic lupus erythematosus, illustrating its significance in cellular homeostasis.
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    Research cited in this study 18

    1. Dissecting Hair Breakage in Alopecia Areata: The Central Role of Dysregulated Cysteine Homeostasis Amino Acids · 2024
    2. Ritlecitinib: First Approval Drugs · 2023
    3. Janus Kinase Inhibitors for Alopecia Areata Journal of the American Academy of Dermatology · 2023
    4. The Crosstalk Between PTEN-Induced Kinase 1-Mediated Mitophagy and the Inflammasome in the Pathogenesis of Alopecia Areata Experimental Dermatology · 2023
    5. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    6. Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches Antioxidants · 2023
    7. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    8. BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy Experimental cell research · 2019
    9. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    10. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    11. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    12. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    13. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    14. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling PloS one · 2014
    15. Hair Growth Activity of Crataegus Pinnatifida on C57BL/6 Mouse Model Phytotherapy Research · 2012
    16. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    17. Prevention and Treatment of Alopecia Areata with Quercetin in the C3H/HeJ Mouse Model Cell stress & chaperones · 2011
    18. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010

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