Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist
February 2023
in “Journal of nanobiotechnology”
TLDR The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.
The document presents a study on a novel anti-acne treatment using a bioconjugate nanoparticle named HA-P5, which is a combination of hyaluronic acid (HA) and a peptide derived from fibroblast growth factors 2 (FGF2). HA-P5 was found to suppress both fibroblast growth factor receptor 2 (FGFR2) and androgen receptor (AR) signalling, which are implicated in acne development. The treatment was effective in reducing acne lesions and sebum production both in vivo and in vitro. HA-P5 also avoids the overexpression of AKR1C3, an enzyme that can interfere with acne treatment by promoting testosterone synthesis, which is a significant advantage over the commercial FGFR inhibitor AZD4547. The study highlights the role of YTHDF3, a molecule involved in AR translation, in the signalling pathway between FGFR2 and AR. The findings suggest that HA-P5 could be a promising new treatment for acne with a dual mechanism of action on FGFR2 and AR signalling pathways.
View this study on jnanobiotechnology.biomedcentral.com →
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