Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of Omics-Based Approaches

December 2018 in “ IntechOpen eBooks ”

Henry Ademola Adeola, Jennifer C. Van Wyk, Afolake Arowolo, Nonhlanhla P. Khumalo

Studysummary This review discusses the potential of using human hair proteomics for non-invasive diagnostic and forensic applications but reports no new results; the authors highlight areas needing further research.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Keratin Network Modifications Lead to the Mechanical Stiffening of the Hair Follicle Fiber

40 citations , May 2016 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that the mechanical stiffening of the human hair follicle along the first millimeter is linked to changes in the keratin network architecture and composition during keratinization.

research Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses

10 citations , January 2016 in “PLOS ONE”

This study investigated protein expression changes during mouse hair follicle cycles and suggested their involvement in biological networks, potentially identifying targets for hair disease therapy.

research Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia

10 citations , June 2015 in “Seminars in cutaneous medicine and surgery”

This review discusses the biology of hair follicles and mechanisms behind various hair disorders, but it presents no new findings; the authors emphasize understanding these concepts to inform treatment development.

research The Structure of People's Hair

107 citations , October 2014 in “PeerJ”

This study found that while molecular hair structures were nearly identical across individuals, genetic factors seem to influence specific lipid compositions, as seen in identical-patterned hair from parent-child pairs and identical twins, but not fraternal twins.

research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis

68 citations , August 2014 in “PeerJ”

This study found that proteomic analysis can distinguish hair samples across different ethnicities and body regions based on keratin protein levels, which may aid forensic hair identification.

research Nanotechnology in Dermatology

60 citations , January 2014 in “Anais Brasileiros De Dermatologia”

This article discusses the foundational concepts of nanotechnology and its contributions to dermatology and medicine, but does not present new research findings.

research Keratins and Lipids in Ethnic Hair

55 citations , January 2013 in “International Journal of Cosmetic Science”

In this study, researchers found that higher concentrations of internal lipids in African hair may influence its keratin structure, as observed through various analytical methods.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research The Proteomic Profile of Hair Damage

20 citations , June 2012 in “British Journal of Dermatology”

This study discusses the proteomic profile associated with hair damage but does not report new experimental findings.

research Identification of Breast Cancer-Associated Lipids in Scalp Hair

6 citations , January 2012 in “Breast cancer”

This study suggests that breast cancer-associated phospholipids may alter the X-ray diffraction pattern of hair, potentially enabling the development of a sensitive and specific screening test for breast cancer.

research Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex

21 citations , October 2011 in “PloS one”

In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.

Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

research Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

38 citations , October 2011 in “Analytical biochemistry”

This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.

Measuring Changes in Chemistry, Composition, and Molecular Structure Within Hair Fibers by Infrared and Raman Spectroscopic Imaging

research Measuring Changes in Chemistry, Composition, and Molecular Structure Within Hair Fibers by Infrared and Raman Spectroscopic Imaging

42 citations , January 2011 in “Journal of Biomedical Optics”

This study demonstrates that spatially resolved IR and Raman imaging can effectively reveal the molecular structure and composition of untreated human hair, providing insights into its chemistry and structural integrity.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.

research Diagnosis of Hair Disorders

73 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

This article reviews various diagnostic tools for hair disorders, describing methods ranging from invasive to noninvasive, but reports no new research findings or clinical results.

research Characterization of a Test for Invasive Breast Cancer Using X-Ray Diffraction of Hair—Results of a Clinical Trial

12 citations , January 2009 in “Breast Cancer Basic and Clinical Research”

This study found that the combination of mammography and hair X-ray diffraction increased sensitivity for detecting breast cancer compared to using each method alone.

research Exogen Hair Characterization in Human Scalp

35 citations , March 2007 in “Skin Research and Technology”

In this study, researchers developed a non-invasive method to distinguish exogen hair from telogen hair on the human scalp, finding that normal exogen hair levels are generally less than seven hairs per cm².

research Proteome Analysis of Human Hair Shaft

122 citations , January 2006 in “Molecular & Cellular Proteomics”

This study found that keratin and other hair proteins in humans are extensively modified posttranslationally, which helps explain the structural characteristics of mature hair.

research Characterization of the Lipid Composition at the Proximal Root Regions of Human Hair

41 citations , May 2005 in “International Journal of Cosmetic Science”

This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.

research Fourier Transform Infrared Attenuated Total Reflection Analysis of Human Hair: Comparison of Hair from Breast Cancer Patients with Hair from Healthy Subjects

42 citations , January 2005 in “Applied spectroscopy”

In this study, hair samples from breast cancer patients showed increased β-sheet structures and lipid content, with spectral markers successfully identifying cancer in a blind test but also producing false positives.

research Hair Protein Glycation as a Long-Term Index of Blood Glucose in Diabetics

5 citations , October 1988 in “Diabetes Research and Clinical Practice”

Hair glycation can indicate long-term blood sugar trends in diabetics.