Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of Omics-Based Approaches

December 2018 in “ IntechOpen eBooks ”

Henry Ademola Adeola, Jennifer C. Van Wyk, Afolake Arowolo, Nonhlanhla P. Khumalo

TLDR Human hair shows promise for non-invasive medical testing, but more research is needed to standardize its use.

The document from 2018 explores the use of human hair as a non-invasive substrate for testing in precision medicine, emphasizing its ability to reflect long-term health and disease information. Hair testing has applications in monitoring drug compliance, detecting chronic alcohol abuse, and discovering biomarkers. The document reviews hair's biochemical structure and its historical and current medical applications, including monitoring HIV/AIDS and tuberculosis treatments. It also discusses the use of hair cortisol levels as a stress biomarker, the detection of ethyl glucuronide for alcohol abuse, and the correlation between hair chromium levels and diabetes. Omics-based approaches, such as proteomics, lipidomics, and metabolomics, have identified biomarkers for conditions like oxidative damage, autoimmune diseases, and cancer risks. The document highlights the importance of data repositories, bioinformatics, and integrative multi-omics methods for molecular analysis, as well as molecular imaging techniques for hair characterization. It also mentions the potential of nanotechnology and Fourier transform infrared (FTIR) imaging in hair analysis. The conclusion suggests that while hair testing holds promise for precision medicine, routine use in diagnostic pathology faces challenges, and more work is needed to establish a standard workflow.

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Research cited in this study

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research Keratin Network Modifications Lead to the Mechanical Stiffening of the Hair Follicle Fiber

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research Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses

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research Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia

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research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis

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research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

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research Identification of Breast Cancer-Associated Lipids in Scalp Hair

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research Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex

21 citations, October 2011 in “PloS one”

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Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

research Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

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Hair proteins have weak spots in their α-helical segments.

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research Measuring Changes in Chemistry, Composition, and Molecular Structure Within Hair Fibers by Infrared and Raman Spectroscopic Imaging

42 citations, January 2011 in “Journal of Biomedical Optics”

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research Biology and Genetics of Hair

89 citations, September 2010 in “Annual Review of Genomics and Human Genetics”

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research Diagnosis of Hair Disorders

73 citations, March 2009 in “Seminars in Cutaneous Medicine and Surgery”

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research Exogen Hair Characterization in Human Scalp

35 citations, March 2007 in “Skin Research and Technology”

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research Characterization of the Lipid Composition at the Proximal Root Regions of Human Hair

41 citations, May 2005 in “International Journal of Cosmetic Science”

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research Fourier Transform Infrared Attenuated Total Reflection Analysis of Human Hair: Comparison of Hair from Breast Cancer Patients with Hair from Healthy Subjects

42 citations, January 2005 in “Applied spectroscopy”

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