Urinary Androgens Provide Additional Evidence Related to Metabolism and Are Correlated With Serum Androgens in Girls

    January 2024 in “ Journal of the Endocrine Society ”
    Sasinya N. Scott, Marvin Siguencia, Frank Z. Stanczyk, Michaela F. Hartmann, Stefan A. Wudy, Melissa White, Wendy K. Chung, Regina M. Santella, Mary Beth Terry, Lauren C. Houghton
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    TLDR The research found that measuring androgens in urine can give extra information about body metabolism and is linked to androgen levels in the blood, especially in young girls.
    The study with 44 girls aged 6-13 found a significant correlation between urinary and serum androgens, suggesting that urinary androgen metabolites can serve as a good marker for circulating androstenedione, testosterone, and free testosterone. The summed urinary metabolite measures correlated most strongly with serum free testosterone (r=0.83) and least with serum DHEA-S (r=0.64). Individual metabolites varied in their correlation (ranging from 0.08 to 0.84) with serum androgens. Factors such as age, weight, height, waist:hip ratio, and pubic hair growth stage significantly affected these correlations. The study indicates that urinary androgens can provide additional insights into metabolic processes related to disease development in comparison to serum androgens.
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