Urinary Androgens Provide Additional Evidence Related to Metabolism and Are Correlated With Serum Androgens in Girls

    January 2024 in “ Journal of the Endocrine Society ”
    Sasinya N. Scott, Marvin Siguencia, Frank Z. Stanczyk, Michaela F. Hartmann, Stefan A. Wudy, Melissa White, Wendy K. Chung, Regina M. Santella, Mary Beth Terry, Lauren C. Houghton
    Image of study
    TLDR The research found that measuring androgens in urine can give extra information about body metabolism and is linked to androgen levels in the blood, especially in young girls.
    The study with 44 girls aged 6-13 found a significant correlation between urinary and serum androgens, suggesting that urinary androgen metabolites can serve as a good marker for circulating androstenedione, testosterone, and free testosterone. The summed urinary metabolite measures correlated most strongly with serum free testosterone (r=0.83) and least with serum DHEA-S (r=0.64). Individual metabolites varied in their correlation (ranging from 0.08 to 0.84) with serum androgens. Factors such as age, weight, height, waist:hip ratio, and pubic hair growth stage significantly affected these correlations. The study indicates that urinary androgens can provide additional insights into metabolic processes related to disease development in comparison to serum androgens.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 18 results

    Similar Research

    5 / 1000+ results
      Androgens and the Menopause

      research Androgens and the Menopause

      6 citations, September 1998 in “The Journal of The British Menopause Society”
      Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.
      Androgen Excess: Investigations and Management

      research Androgen Excess: Investigations and Management

      82 citations, May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”
      The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.
      The Use of Testosterone After Menopause

      research The Use of Testosterone After Menopause

      5 citations, June 2004 in “The Journal of The British Menopause Society”
      Testosterone therapy can improve sexual satisfaction and mood in surgically menopausal women when used with estrogen, but its long-term safety and effects on naturally menopausal and premenopausal women are unclear.
      Clinical Biochemistry of Dihydrotestosterone

      research Clinical Biochemistry of Dihydrotestosterone

      50 citations, February 2013 in “Annals of Clinical Biochemistry”
      Understanding how DHT works is important for diagnosing and treating hormone-related disorders.