Hair Regrowth Boosting Via Minoxidil Cubosomes: Formulation Development, In Vivo Hair Regrowth Evaluation, Histopathological Examination, and Confocal Laser Microscopy Imaging

    February 2023 in “ International Journal of Pharmaceutics ”
    Amal Makhlouf, Tayseer Elnawawy
    Studysummary In this study, the researchers developed minoxidil cubosomes using nanotechnology, which improved drug penetration in the skin, showed greater hair growth efficacy, and reduced adverse skin reactions compared to traditional minoxidil solutions.
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    Research cited in this study 18

    1. Development of Minoxidil-Loaded Double Emulsion PLGA Nanoparticles for the Treatment of Hair Loss Journal of Industrial and Engineering Chemistry · 2022
    2. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    3. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020
    4. The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia Pharmacology Research & Perspectives · 2020
    5. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy International Journal of Molecular Sciences · 2020
    6. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    7. A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women Dermatologic Surgery · 2019
    8. The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern American Journal of Clinical Dermatology · 2018
    9. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery Medicines · 2018
    10. Evaluation of Animal Models Suitable for Hair Research and Regeneration InTech eBooks · 2018
    11. Review of Quality of Life Studies in Women with Alopecia International Journal of Women's Dermatology · 2018
    12. A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors Medical Hypotheses · 2017
    13. Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine Journal of Drug Delivery Science and Technology · 2017
    14. Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats European Journal of Pharmaceutics and Biopharmaceutics · 2017
    15. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    16. Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model Annals of Dermatology · 2016
    17. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    18. New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment Drug Development and Industrial Pharmacy · 2014