Hair Regeneration by Small Molecules That Activate Autophagy

The study explored the potential of small molecules that activate autophagy to stimulate hair regeneration. Researchers identified that longevity metabolites such as α-ketoglutarate and α-ketobutyrate, along with prescription drugs like rapamycin and metformin, which affect TOR and AMPK signaling pathways, could promote hair growth. This finding suggested a promising avenue for developing treatments for hair loss or alopecia, which affects millions globally due to various factors including aging, hormonal issues, autoimmunity, and cancer treatments.