Hair Regeneration by Small Molecules That Activate Autophagy

January 2018 in “ Social Science Research Network ”

Min Chai, Meisheng Jiang, Laurent Vergnes, Xudong Fu, Stéphanie C. de Barros, Jing Jiao, Harvey R. Herschman, Karen Reue, Jing Huang

autophagy α-ketoglutarate α-ketobutyrate rapamycin metformin TOR signaling pathway AMPK signaling pathway alopecia hair regeneration hormonal dysfunction autoimmunity hair loss hair growth TOR pathway AMPK pathway

From the encyclopedia

Rapamycin →

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

Metformin →

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

Studysummary This study reports that hair regeneration can be stimulated by small molecules like α-ketoglutarate, α-ketobutyrate, rapamycin, and metformin, which activate autophagy pathways.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations , March 2018 in “PLOS Biology”

This study found that autophagy plays a novel role in human hair growth, with altered autophagic flux during hair development phases influencing hair follicle behavior in a preclinical model.

research Caloric Restriction Promotes Structural and Metabolic Changes in the Skin

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Caloric restriction improves skin and fur structure but can cause muscle loss and movement issues.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.

Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

This study found that mTOR signaling plays a crucial role in activating hair follicle stem cells by balancing BMP-mediated repression, essential for hair regeneration.

research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

277 citations , February 2013 in “Science Signaling”

This study found that mitochondrial reactive oxygen species are crucial for normal epidermal differentiation and hair follicle growth, as demonstrated by impaired development in mice lacking these signals due to a keratinocyte-specific TFAM deficiency.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.

research Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles

28 citations , November 2012 in “Experimental dermatology”

This study suggests that mTORC1 may play a role in regulating the timing of hair growth cycle phases, particularly the initiation of the anagen phase.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth

109 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.