Hair Growth Effect of TS-SCLF from Schisandra Chinensis Extract Fermented with Lactobacillus Plantarum

December 2022 in “ 한국 미생물 생명공학회지 ”

Youngmin Woo, Jihoon Seo, Soo-ya Kim, Jae Chun Hyun, Hyun Dae Cho, Young Chul Kwon, Ju Tae Jeong, Sung Min Park, Hwa Sun Ryu, Jae Mun Kim, Moon Hoy Kim, Hee-Taek Kim, Yongmin Kim, Kwang Sik Joo, Sun Mi Lee, Jungno Lee, Andre Kim

TS-SCLF Schisandra chinensis Lactobacillus plantarum gomisin N lignan-based compound human dermal papilla cells growth factors hair loss hair thickness hair quality hair quantity Schisandra Lactobacillus dermal papilla cells

Studysummary TS-SCLF from fermented Schisandra chinensis may promote hair growth and improve hair quality. Our plain-language summary of this paper — not a Tressless recommendation.

The research examined the hair growth effects of TS-SCLF, a compound derived from Schisandra chinensis fermented with Lactobacillus plantarum. The compound was identified as gomisin N, a lignan-based compound. The study involved both in vitro experiments on human dermal papilla cells and a clinical trial with 58 participants aged 19-54. The in vitro tests showed that the extract promoted cell proliferation and increased the secretion of various growth factors. The clinical trial, which used a shampoo containing TS-SCLF for 24 weeks, demonstrated improvements in hair loss, thickness, quality, and quantity. The study concluded that TS-SCLF has potential as a hair growth-promoting agent.

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research Comparison of Saccharina Japonica–Undaria Pinnatifida Mixture and Minoxidil on Hair Growth Promoting Effect in Mice

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research An Assessment of Hair Loss Ameliorating Effect of Medicinal Plant Extracts, Amino Acid and Vitamin Complex in Human Subjects

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research Hair Growth Promoting Effect of Black Soybean Extract In Vitro and In Vivo

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research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

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research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

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