Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol), Adenosine, and Minoxidil in Human Dermal Papilla Cells

June 2017 in “ Journal of biomedicine and translational research ”

Koji Wakame, Akifumi Nakata, Keisuke Sato, Yoshihiro Mihara, Jun Takanari, Atuya Sato, Kenichi Komatsu

Low-Molecular-Weight Lychee Fruit Polyphenol Oligonol Adenosine Minoxidil human dermal papilla cells VEGF FGF-7 WNT5a WNT10a mRNA DNA microarray inflammation-related genes cell proliferation Rogaine

TLDR Lychee fruit polyphenol (Oligonol®) may regulate genes linked to cell growth and inflammation in human scalp cells.

The 2017 study investigated the effects of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil on human dermal papilla cells at the genetic level. The substances were applied to human dermal papilla cell lines for 24 hours, and the expressions of VEGF, FGF-7, WNT5a, and WNT10a mRNA were measured. The results showed that FGF-7 and WNT10a mRNA expression were observed in cells supplemented with 100 µg/mL Oligonol®. Additionally, DNA microarray analysis showed that Oligonol® suppressed 10 inflammation-related genes. The study concluded that Oligonol® could potentially affect the function of human dermal papilla cells by regulating the expression of genes related to cell proliferation and inflammation.

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