Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol), Adenosine, and Minoxidil in Human Dermal Papilla Cells

June 2017 in “ Journal of biomedicine and translational research ”

Koji Wakame, Akifumi Nakata, Keisuke Sato, Yoshihiro Mihara, Jun Takanari, Atuya Sato, Kenichi Komatsu

Low-Molecular-Weight Lychee Fruit Polyphenol Oligonol Adenosine Minoxidil human dermal papilla cells VEGF FGF-7 WNT5a WNT10a mRNA DNA microarray inflammation-related genes cell proliferation Rogaine

TLDR Lychee fruit polyphenol (Oligonol®) may regulate genes linked to cell growth and inflammation in human scalp cells.

The 2017 study investigated the effects of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil on human dermal papilla cells at the genetic level. The substances were applied to human dermal papilla cell lines for 24 hours, and the expressions of VEGF, FGF-7, WNT5a, and WNT10a mRNA were measured. The results showed that FGF-7 and WNT10a mRNA expression were observed in cells supplemented with 100 µg/mL Oligonol®. Additionally, DNA microarray analysis showed that Oligonol® suppressed 10 inflammation-related genes. The study concluded that Oligonol® could potentially affect the function of human dermal papilla cells by regulating the expression of genes related to cell proliferation and inflammation.

View this study on ejournal2.undip.ac.id →

Discuss this study in the Community →

7 / 7 results

research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

November 2021 in “Research Square (Research Square)”

3D spheroid cultures of human hair follicle cells are better for hair growth research than 2D cultures, and they provide new insights into how hair growth treatments like minoxidil and TCQA work.